Disorder-to-order active site capping regulates the rate-limiting step of the inositol pathway.

Catalytic Domain Myo-Inositol-1-Phosphate Synthase / metabolism Inositol / metabolism Inositol Phosphates / metabolism Glucose-6-Phosphate / metabolism Models, Molecular Protein Conformation Fungal Proteins / metabolism
conformational selection cryo-EM endogenous induced fit inositol metabolism

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
20 Aug 2024
Historique:
medline: 15 8 2024
pubmed: 15 8 2024
entrez: 15 8 2024
Statut: ppublish

Résumé

Myo-inositol-1-phosphate synthase (MIPS) catalyzes the NAD

Identifiants

DOI: 10.1073/pnas.2400912121 PMID: 39145930
pubmed: 39145930
doi: 10.1073/pnas.2400912121
doi:

Substances chimiques

Myo-Inositol-1-Phosphate Synthase EC 5.5.1.4
Inositol 4L6452S749
Inositol Phosphates 0
Glucose-6-Phosphate 56-73-5
Fungal Proteins 0
inositol 1-phosphate 15421-51-9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2400912121

Subventions

Organisme : Bundesministerium für Bildung und Forschung (BMBF)
ID : 03Z22HN22
Organisme : Bundesministerium für Bildung und Forschung (BMBF)
ID : 03Z22HI2
Organisme : Bundesministerium für Bildung und Forschung (BMBF)
ID : 03Z22HN23
Organisme : Bundesministerium für Bildung und Forschung (BMBF)
ID : 03Z22HI2
Organisme : Bundesministerium für Bildung und Forschung (BMBF)
ID : 03COV04
Organisme : EC | Horizon Europe | WPSERA | HORIZON EUROPE Widening participation and spreading excellence (WPSE)
ID : 101086665
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : 391498659

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Toni K Träger (TK)

Faculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Biozentrum, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
ORCID: 0000-0002-7001-2619

Fotis L Kyrilis (FL)

Institute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.
ORCID: 0000-0002-4040-6289

Farzad Hamdi (F)

Faculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Biozentrum, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
ORCID: 0000-0002-2155-5000

Christian Tüting (C)

Faculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Biozentrum, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
ORCID: 0000-0001-6209-4012

Marie Alfes (M)

Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Biologics Analytical R&D, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen 67061, Germany.
ORCID: 0000-0001-5006-9573

Tommy Hofmann (T)

Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Impfstoffwerk Dessau-Tornau Biologika, Dessau-Roßlau 06861, Germany.
ORCID: 0000-0002-9646-7136

Carla Schmidt (C)

Faculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Department of Chemistry-Biochemistry, Johannes Gutenberg University Mainz, Mainz 55128, Germany.
ORCID: 0000-0001-9410-1424

Panagiotis L Kastritis (PL)

Faculty of Natural Sciences I, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Biozentrum, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Institute of Chemical Biology, National Hellenic Research Foundation, Athens 11635, Greece.
Interdisciplinary Research Center HALOmem, Charles Tanford Protein Center, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
ORCID: 0000-0002-1463-8422

Articles similaires

Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases.

Arpine Sokratian, Ye Zhou, Meltem Tatli et al.
1.00
alpha-Synuclein Humans Animals Mice Lewy Body Disease

Menthol as an effective inhibitor of quorum sensing and biofilm formation in Candida albicans and Candida glabrata by targeting the transcriptional repressor TUP1.

Pouria Khodavandi, Maryam Miri Soogh, Fahimeh Alizadeh et al.
1.00
Biofilms Candida albicans Quorum Sensing Candida glabrata Menthol

Mutational analysis of Phanerochaete chrysosporium´s purine transporter.

Mariana Barraco-Vega, Manuel Sanguinetti, Gabriela da Rosa et al.
1.00
Phanerochaete Fungal Proteins Purines Aspergillus nidulans DNA Mutational Analysis

Structural basis for molecular assembly of fucoxanthin chlorophyll

Koji Kato, Yoshiki Nakajima, Jian Xing et al.
1.00
Diatoms Photosystem I Protein Complex Chlorophyll Binding Proteins Cryoelectron Microscopy Light-Harvesting Protein Complexes

Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Disorder-to-order active site capping...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Lyases intramoléculaires › Myo-inositol 1-phosphate synthase › Disorder-to-order active site capping...
questionsmedicales.fr › Glucides › Polyols › Inositol › Disorder-to-order active site capping...
questionsmedicales.fr › Glucides › Oses phosphates › Inositol phosphates › Disorder-to-order active site capping...
questionsmedicales.fr › Glucides › Oses phosphates › Hexose phosphate › Glucose phosphate › Glucose-6-phosphate › Disorder-to-order active site capping...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Disorder-to-order active site capping...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Disorder-to-order active site capping...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Disorder-to-order active site capping...