Protection of stromal cell-derived factor-1 SDF-1/CXCL12 against proteases yields improved skin wound healing.
COAM
CXCL12
SDF-1
chemokine
proteolysis
wound healing
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
21
12
2023
accepted:
18
07
2024
medline:
19
8
2024
pubmed:
19
8
2024
entrez:
19
8
2024
Statut:
epublish
Résumé
SDF-1/CXCL12 is a unique chemotactic factor with multiple functions on various types of precursor cells, all carrying the cognate receptor CXCR4. Whereas individual biological functions of SDF-1/CXCL12 have been well documented, practical applications in medicine are insufficiently studied. This is explained by the complex multifunctional biology of SDF-1 with systemic and local effects, critical dependence of SDF-1 activity on aminoterminal proteolytic processing and limited knowledge of applicable modulators of its activity. We here present new insights into modulation of SDF-1 activity
Identifiants
pubmed: 39156898
doi: 10.3389/fimmu.2024.1359497
pmc: PMC11327020
doi:
Substances chimiques
Chemokine CXCL12
0
Dipeptidyl Peptidase 4
EC 3.4.14.5
Receptors, CXCR4
0
Matrix Metalloproteinase 9
EC 3.4.24.35
CXCL12 protein, human
0
Cxcl12 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1359497Informations de copyright
Copyright © 2024 Pereira, EzEldeen, Ugarte-Berzal, Vandooren, Martens, Gouwy, Ganseman, Van Damme, Matthys, Vranckx, Proost and Opdenakker.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.