Feasibility, reproducibility, and accuracy of echocardiographic right ventricular systolic function assessments in childhood cancer survivors at risk for heart failure.
Humans
Male
Female
Reproducibility of Results
Adolescent
Feasibility Studies
Young Adult
Prospective Studies
Adult
Heart Failure
/ physiopathology
Cancer Survivors
/ statistics & numerical data
Echocardiography
/ methods
Heart Ventricles
/ diagnostic imaging
Ventricular Function, Right
/ physiology
Systole
Ventricular Dysfunction, Right
/ physiopathology
Neoplasms
/ complications
Magnetic Resonance Imaging, Cine
/ methods
Stroke Volume
/ physiology
adolescent and young adult
anthracycline cardiotoxicity
cardio‐oncology
childhood cancer survivors
echocardiographic strain
pediatric echocardiography
right ventricular function
three‐dimensional echocardiography
Journal
Echocardiography (Mount Kisco, N.Y.)
ISSN: 1540-8175
Titre abrégé: Echocardiography
Pays: United States
ID NLM: 8511187
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
revised:
26
07
2024
received:
31
05
2024
accepted:
04
08
2024
medline:
19
8
2024
pubmed:
19
8
2024
entrez:
19
8
2024
Statut:
ppublish
Résumé
We sought to assess the feasibility, reproducibility, and accuracy of conventional and newer echocardiographic measures of right ventricular (RV) systolic function in adolescent and young adult childhood cancer survivors treated with anthracyclines. Echocardiography and cardiac magnetic resonance imaging (CMR) were acquired ≤60 days apart in prospectively recruited survivors and RV functional measures were quantitated by blinded observers. Repeat quantitation was performed in a subset to evaluate reproducibility. For each echocardiographic measure, Spearman correlations with CMR measures were calculated, and values in participants with CMR RV ejection fraction (RVEF) ≥48% and RVEF <48% were compared using two sample Wilcoxon rank-sum tests. Among 58 participants, mean age was 18.2 years (range 13.1-25.2) and five participants had CMR RVEF <48%. Intra- and inter-observer coefficients of variation were 8.2%-10.1% and 10.5%-12.0% for adjusted automated strain measures, and 5.2%-8.7% and 2.7% for 3D RVEF, respectively. No echocardiographic measures were significantly correlated with CMR RVEF; only tricuspid annular plane systolic excursion was correlated with CMR RV stroke volume (r = .392, p = .003). Participants with RV dysfunction had worse automated global longitudinal strain (-20.3% vs. -23.9%, p = .007) and free wall longitudinal strain (-23.7% vs. -26.7%, p = .09). Echocardiographic strain and 3D RV function measurements were feasible and reproducible in at-risk childhood cancer survivors. Although not associated with CMR RVEF in this population with predominantly normal RV function, automated strain measurements were more abnormal in participants with RV dysfunction, suggesting potential clinical utility of these measures.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15905Subventions
Organisme : Padres Pedal the Cause/RADY
ID : PTC2020
Organisme : UC San Diego Moore Cancer Center
Organisme : Specialized Cancer Control Support
ID : NIH/NCI P30CA023100
Organisme : NIH HHS
ID : K23 HL163456
Pays : United States
Organisme : TEAM ABBY Gives: St. Baldrick's Foundation Scholar Award
Organisme : NCATS NIH HHS
ID : UL1TR001442
Pays : United States
Organisme : Ada Durairaj Research Grant
Informations de copyright
© 2024 The Author(s). Echocardiography published by Wiley Periodicals LLC.
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