Gcn2 structurally mimics and functionally repurposes the HisRS enzyme for the integrated stress response.

Chaetomium / enzymology Protein Serine-Threonine Kinases / metabolism Histidine-tRNA Ligase / metabolism Stress, Physiological Fungal Proteins / metabolism Crystallography, X-Ray Models, Molecular Protein Domains Saccharomyces cerevisiae Proteins / metabolism
GCN4 translation Gcn2 eIF2α phosphorylation histidyl-tRNA synthetase yeast S. cerevisiae

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
27 Aug 2024
Historique:
medline: 20 8 2024
pubmed: 20 8 2024
entrez: 20 8 2024
Statut: ppublish

Résumé

Protein kinase Gcn2 attenuates protein synthesis in response to amino acid starvation while stimulating translation of a transcriptional activator of amino acid biosynthesis. Gcn2 activation requires a domain related to histidyl-tRNA synthetase (HisRS), the enzyme that aminoacylates tRNA

Identifiants

DOI: 10.1073/pnas.2409628121 PMID: 39163341
pubmed: 39163341
doi: 10.1073/pnas.2409628121
doi:

Substances chimiques

Protein Serine-Threonine Kinases EC 2.7.11.1
Histidine-tRNA Ligase EC 6.1.1.21
Fungal Proteins 0
Saccharomyces cerevisiae Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2409628121

Subventions

Organisme : HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
ID : HD001004
Organisme : HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM)
ID : ZIADK075136

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Charles Bou-Nader (C)

Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.

Swati Gaikwad (S)

Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
ORCID: 0000-0002-1438-9497

Soheila Bahmanjah (S)

Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.

Fan Zhang (F)

Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.

Alan G Hinnebusch (AG)

Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
ORCID: 0000-0002-1627-8395

Jinwei Zhang (J)

Laboratory of Molecular Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Sordariales › Chaetomium › Gcn2 structurally mimics and functionally...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Gcn2 structurally mimics and functionally...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-oxygen ligases › Amino acyl-tRNA synthetases › Histidine-tRNA ligase › Gcn2 structurally mimics and functionally...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Gcn2 structurally mimics and functionally...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Gcn2 structurally mimics and functionally...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Gcn2 structurally mimics and functionally...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Gcn2 structurally mimics and functionally...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Gcn2 structurally mimics and functionally...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Gcn2 structurally mimics and functionally...