Angiotensin II Type 2 Receptor Antibodies in Glomerular Diseases.
Humans
Female
Male
Middle Aged
Adult
Receptor, Angiotensin, Type 2
/ immunology
Autoantibodies
/ blood
Aged
Kidney Glomerulus
/ immunology
Glomerulonephritis, Membranous
/ immunology
Glomerulonephritis
/ immunology
Antibodies, Antineutrophil Cytoplasmic
/ immunology
Lupus Erythematosus, Systemic
/ immunology
Glomerulonephritis, IGA
/ immunology
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
/ immunology
Lupus Nephritis
/ immunology
Receptor, Angiotensin, Type 1
/ immunology
Young Adult
Kidney Diseases
/ immunology
Angiotensin II type 2 receptor
Antibodies
Glomerulonephritis
Lupus
Journal
Archivum immunologiae et therapiae experimentalis
ISSN: 1661-4917
Titre abrégé: Arch Immunol Ther Exp (Warsz)
Pays: Poland
ID NLM: 0114365
Informations de publication
Date de publication:
01 Jan 2024
01 Jan 2024
Historique:
received:
24
01
2024
accepted:
24
06
2024
medline:
21
8
2024
pubmed:
21
8
2024
entrez:
21
8
2024
Statut:
epublish
Résumé
We evaluated the concentration of AT2R antibodies in 136 patients with primary and secondary glomerular diseases: membranous nephropathy (n = 18), focal and segmental glomerulosclerosis (n = 25), systemic lupus erythematosus (n = 17), immunoglobulin A (IgA) nephropathy (n = 14), mesangial (non-IgA) proliferative nephropathy (n = 6), c-ANCA vasculitis (n = 40), perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) vasculitis (n = 16), and compared it with a healthy control group (22 patients). Serum creatinine levels, proteinuria, serum albumin, and total protein concentrations were prospectively recorded for 2 years. The mean levels of AT2R antibodies in the lupus nephropathy group were significantly higher compared to the control group, 64.12 ± 26.95 units/mL and 9.72 ± 11.88 units/mL, respectively. There was no association between this level and the clinical course of the disease. The AT2R levels in other kinds of glomerular disease were no different from the control group. We found significant correlations between AT1R and AT2R in patients with membranous nephropathy (r = 0.66), IgA nephropathy (r = 0.61), and c-ANCA vasculitis (r = 0.63). Levels of AT2R antibodies in systemic lupus erythematosus are higher compared to other types of glomerulonephritis, vasculitis, and a healthy control group. Levels of AT2R antibodies correlate with AT1R antibodies in the groups of patients with membranous nephropathy, IgA nephropathy, and c-ANCA vasculitis. These kinds of AT2R antibodies have a stimulative effect on AT2R, but we have not found the influence of these antibodies on the clinical course of glomerular diseases.
Identifiants
pubmed: 39166802
pii: aite-2024-0017
doi: 10.2478/aite-2024-0017
doi:
Substances chimiques
Receptor, Angiotensin, Type 2
0
Autoantibodies
0
Antibodies, Antineutrophil Cytoplasmic
0
Receptor, Angiotensin, Type 1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 Maciej Szymczak et al., published by Sciendo.
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