nnU-Net-based Segmentation of Tumor Subcompartments in Pediatric Medulloblastoma Using Multiparametric MRI: A Multi-institutional Study.

Humans Medulloblastoma / diagnostic imaging Child Adolescent Female Male Retrospective Studies Cerebellar Neoplasms / diagnostic imaging Child, Preschool Multiparametric Magnetic Resonance Imaging / methods Deep Learning Image Interpretation, Computer-Assisted / methods Neural Networks, Computer
MR Imaging MRI Medulloblastoma Pediatrics Segmentation Transfer Learning nnU-Net

Journal

Radiology. Artificial intelligence
ISSN: 2638-6100
Titre abrégé: Radiol Artif Intell
Pays: United States
ID NLM: 101746556

Informations de publication

Date de publication:
Sep 2024
Historique:
medline: 20 9 2024
pubmed: 21 8 2024
entrez: 21 8 2024
Statut: ppublish

Résumé

Purpose To evaluate nnU-Net-based segmentation models for automated delineation of medulloblastoma tumors on multi-institutional MRI scans. Materials and Methods This retrospective study included 78 pediatric patients (52 male, 26 female), with ages ranging from 2 to 18 years, with medulloblastomas, from three different sites (28 from hospital A, 18 from hospital B, and 32 from hospital C), who had data available from three clinical MRI protocols (gadolinium-enhanced T1-weighted, T2-weighted, and fluid-attenuated inversion recovery). The scans were retrospectively collected from the year 2000 until May 2019. Reference standard annotations of the tumor habitat, including enhancing tumor, edema, and cystic core plus nonenhancing tumor subcompartments, were performed by two experienced neuroradiologists. Preprocessing included registration to age-appropriate atlases, skull stripping, bias correction, and intensity matching. The two models were trained as follows:

Identifiants

DOI: 10.1148/ryai.230115 PMID: 39166971
pubmed: 39166971
doi: 10.1148/ryai.230115
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

e230115

Commentaires et corrections

Type : CommentIn

Auteurs

Rohan Bareja (R)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0000-0002-0635-7743

Marwa Ismail (M)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0000-0002-1396-0372

Douglas Martin (D)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0000-0003-4266-238X

Ameya Nayate (A)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0000-0001-6846-2074

Ipsa Yadav (I)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0000-0001-5414-7188

Murad Labbad (M)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0009-0006-9403-2266

Prateek Dullur (P)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0009-0005-2094-4038

Sanya Garg (S)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).

Benita Tamrazi (B)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0000-0003-4795-8454

Ralph Salloum (R)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).

Ashley Margol (A)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0000-0002-3038-8005

Alexander Judkins (A)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).

Sukanya Iyer (S)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).

Peter de Blank (P)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).
ORCID: 0000-0001-6623-3040

Pallavi Tiwari (P)

From the Department of Radiology, University of Wisconsin-Madison, Madison, Wis (R.B., M.I., I.Y.); University Hospitals, Cleveland, Ohio (D.M., A.N.); Departments of Biomedical Engineering (M.L., S.G., S.I.) and Neurosciences (P.D.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, Calif (B.T.); Division of Hematology, Oncology & Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio (R.S.); Department of Pediatrics, Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, Calif (A.M.); Department of Pathology, Children's Hospital Los Angeles, Los Angeles, Calif (A.J.); Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (P.d.B.); William S. Middleton Memorial Veterans Affairs (VA) Healthcare, Madison, Wis (P.T.); and Department of Radiology and Biomedical Engineering, University of Wisconsin-Madison, 750 Highland Ave, Madison, WI 53726 (P.T.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Tumeurs neuroectodermiques primitives › Médulloblastome › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Tumeurs sous-tentorielles › Tumeurs du cervelet › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Imagerie par résonance magnétique multiparamétrique › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Intelligence artificielle › Réseaux neuronaux (ordinateur) › Apprentissage profond › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Sciences de l'information › Informatique › Informatique médicale › Applications de l'informatique médicale › Prise de décision assistée par ordinateur › Diagnostic assisté par ordinateur › Interprétation d'images assistée par ordinateur › nnU-Net-based Segmentation of Tumor...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Intelligence artificielle › Réseaux neuronaux (ordinateur) › nnU-Net-based Segmentation of Tumor...