A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors.

Tumor Necrosis Factor alpha-Induced Protein 3 / genetics Animals Humans Homeostasis Haploinsufficiency Mice NF-kappa B / metabolism Mice, Knockout Female Male Signal Transduction Middle Aged Lymphocytes / immunology B-Lymphocytes / immunology Adult Tumor Necrosis Factor-alpha / metabolism T-Lymphocytes / immunology Lymphoma / genetics

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
23 Aug 2024
Historique:
medline: 21 8 2024
pubmed: 21 8 2024
entrez: 21 8 2024
Statut: ppublish

Résumé

Genetic

Identifiants

DOI: 10.1126/sciadv.adl3975 PMID: 39167656
pubmed: 39167656
doi: 10.1126/sciadv.adl3975
doi:

Substances chimiques

Tumor Necrosis Factor alpha-Induced Protein 3 EC 3.4.19.12
TNFAIP3 protein, human EC 3.4.19.12
NF-kappa B 0
Tumor Necrosis Factor-alpha 0
Tnfaip3 protein, mouse EC 3.4.22.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadl3975

Auteurs

Christoph Schultheiß (C)

Division of Medical Oncology, University Hospital Basel, Basel, Switzerland.
Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland.
ORCID: 0000-0001-9789-5776

Lisa Paschold (L)

Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
ORCID: 0000-0003-0020-1315

Alma Nazlie Mohebiany (AN)

Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
Microglia and Inflammation in Neurological Disorders (MIND) Lab, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
ORCID: 0000-0001-9818-6867

Moritz Escher (M)

Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
ORCID: 0009-0001-0059-481X

Yogita Mallu Kattimani (YM)

Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.

Melanie Müller (M)

Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
ORCID: 0009-0009-3082-256X

Paul Schmidt-Barbo (P)

Division of Medical Oncology, University Hospital Basel, Basel, Switzerland.
Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland.
Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany.

Anna Mensa-Vilaró (A)

Department of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

Juan Ignacio Aróstegui (JI)

Department of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
School of Medicine, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0003-4757-504X

Guilaine Boursier (G)

Department of molecular and cytogenomics, Rare and Autoinflammatory Diseases Laboratory, CHU Montpellier, IRMB, University of Montpellier, INSERM, CEREMAIA, Montpellier, France.
ORCID: 0000-0002-2903-3135

Claire de Moreuil (C)

Department of Internal Medicine, CHU Brest, Université de Bretagne Occidentale, Brest, France.

Timo Hautala (T)

Research Unit of Biomedicine, University of Oulu and Department of Internal Medicine, Oulu University Hospital, Oulu, Finland.
ORCID: 0000-0001-7889-1614

Edith Willscher (E)

Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
ORCID: 0000-0002-8786-4578

Hanna Jonas (H)

Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

Namuun Chinchuluun (N)

Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

Bianca Grosser (B)

Institute for Pathology, University Medical Center Augsburg, Augsburg, Germany.

Bruno Märkl (B)

Institute for Pathology, University Medical Center Augsburg, Augsburg, Germany.
ORCID: 0000-0002-7704-850X

Wolfram Klapper (W)

Institute of Pathology, Hematopathology Section, and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Prasad Thomas Oommen (PT)

Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
ORCID: 0000-0003-2893-7252

Katharina Gössling (K)

Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany.

Katrin Hoffmann (K)

Institute for Human Genetics and Molecular Biology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

Gisa Tiegs (G)

Institute for Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Felix Czernilofsky (F)

Department of Medicine V, Hematology, Oncology, and Rheumatology, University of Heidelberg, Heidelberg, Germany.
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.
ORCID: 0000-0001-5868-2890

Sascha Dietrich (S)

Department of Medicine V, Hematology, Oncology, and Rheumatology, University of Heidelberg, Heidelberg, Germany.
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.
Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Hematolgy, Oncology, and Immunolgy, University Hospital of Düsseldorf, Düsseldorf, Germany.

Alexandra Freeman (A)

Laboratory of Clinical Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
ORCID: 0000-0001-7005-8345

Daniella M Schwartz (DM)

Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0002-1660-8438

Ari Waisman (A)

Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
ORCID: 0000-0003-4304-8234

Ivona Aksentijevich (I)

Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-6564-7214

Mascha Binder (M)

Division of Medical Oncology, University Hospital Basel, Basel, Switzerland.
Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland.
Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany.
ORCID: 0000-0003-0663-3004

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéine-3 induite par le facteur de nécrose tumorale alpha › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Eucaryotes › Animaux › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Dosage génique › Haploinsuffisance › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › A20 haploinsufficiency disturbs immune...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › A20 haploinsufficiency disturbs immune...