Ultraselective Macrocycle Membranes for Pharmaceutical Ingredients Separation in Organic Solvents.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 Aug 2024
21 Aug 2024
Historique:
received:
31
03
2024
accepted:
12
08
2024
medline:
22
8
2024
pubmed:
22
8
2024
entrez:
21
8
2024
Statut:
epublish
Résumé
Separations are core processes in the chemical and pharmaceutical industries. Several steps of fractionation and purification of multicomponent mixtures are required. Membrane technology can operate at fair temperatures, saving energy and processing sensitive compounds. However, breakthroughs require high stability and selectivity beyond those available today. Here, we propose membranes constituted by fully crosslinked crown ethers using interfacial polymerization. The 24 nm-thick nanofilms on robust porous supports exhibit up to 90% higher selectivity than commercially available membranes, with a 90% increase in solvent permeance. The membranes are tested with a complex mixture of structurally diverse solutes containing active pharmaceutical ingredients. The membranes are effective for the total retention and concentration of active pharmaceutical ingredients with molecular weights around 800 g mol
Identifiants
pubmed: 39169043
doi: 10.1038/s41467-024-51548-7
pii: 10.1038/s41467-024-51548-7
doi:
Substances chimiques
Solvents
0
Membranes, Artificial
0
Pharmaceutical Preparations
0
Crown Ethers
0
Macrocyclic Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7151Informations de copyright
© 2024. The Author(s).
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