Influence of azathioprine on healing of exposed dogs' dental pulp capped with three different materials.
Animals
Dogs
Azathioprine
/ pharmacology
Dental Pulp Capping
/ veterinary
Oxides
/ pharmacology
Immunosuppressive Agents
/ therapeutic use
Silicates
/ pharmacology
Calcium Compounds
/ pharmacology
Calcium Hydroxide
/ pharmacology
Dog Diseases
/ drug therapy
Aluminum Compounds
/ pharmacology
Dental Pulp
/ drug effects
Drug Combinations
Male
Wound Healing
/ drug effects
Pulp Capping and Pulpectomy Agents
/ pharmacology
Female
Bio-Aggregates
Calcium hydroxide
Dentine bridge
Immunosuppression
Mineral trioxide aggregate.
Journal
Open veterinary journal
ISSN: 2218-6050
Titre abrégé: Open Vet J
Pays: Libya
ID NLM: 101653182
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
received:
16
04
2024
accepted:
08
06
2024
medline:
23
8
2024
pubmed:
23
8
2024
entrez:
23
8
2024
Statut:
ppublish
Résumé
Azathioprine is one of the earliest immunosuppressants prescribed for several autoimmune diseases. Yet there is a lack of research on the impact of azathioprine on pulp healing following the pulp capping procedure. This study aimed to investigate the effect of azathioprine on the healing ability of mechanically exposed dogs' dental pulps following direct pulp capping with mineral trioxide aggregate (MTA), bio-aggregates (BA), and Calcium hydroxide (Ca(OH) Four mongrel dogs were randomly assigned to two groups (two dogs/30 teeth in each group): immunosuppressed (group I) and control (group II). Group I received azathioprine for two months before surgical treatments and until the dogs were euthanized. Fifteen class V buccal cavities were performed in each dog. Each group was randomly divided into three subgroups (10 teeth each) based on the pulp capping substance. The pulps in subgroups A, B, and C were immediately capped with MTA, BA, and Ca(OH) The immunosuppressed group exhibited statistically greater inflammatory cell count and decreased dentine bridge thickness, compared to the control group in all subgroups ( Azathioprine has an adverse effect on the healing of exposed dogs' dental pulp following direct pulp capping with MTA, BA, and Ca(OH)
Sections du résumé
Background
UNASSIGNED
Azathioprine is one of the earliest immunosuppressants prescribed for several autoimmune diseases. Yet there is a lack of research on the impact of azathioprine on pulp healing following the pulp capping procedure.
Aim
UNASSIGNED
This study aimed to investigate the effect of azathioprine on the healing ability of mechanically exposed dogs' dental pulps following direct pulp capping with mineral trioxide aggregate (MTA), bio-aggregates (BA), and Calcium hydroxide (Ca(OH)
Methods
UNASSIGNED
Four mongrel dogs were randomly assigned to two groups (two dogs/30 teeth in each group): immunosuppressed (group I) and control (group II). Group I received azathioprine for two months before surgical treatments and until the dogs were euthanized. Fifteen class V buccal cavities were performed in each dog. Each group was randomly divided into three subgroups (10 teeth each) based on the pulp capping substance. The pulps in subgroups A, B, and C were immediately capped with MTA, BA, and Ca(OH)
Results
UNASSIGNED
The immunosuppressed group exhibited statistically greater inflammatory cell count and decreased dentine bridge thickness, compared to the control group in all subgroups (
Conclusion
UNASSIGNED
Azathioprine has an adverse effect on the healing of exposed dogs' dental pulp following direct pulp capping with MTA, BA, and Ca(OH)
Identifiants
pubmed: 39175985
doi: 10.5455/OVJ.2024.v14.i7.11
pii: OVJ-14-1614
pmc: PMC11338621
doi:
Substances chimiques
Azathioprine
MRK240IY2L
Oxides
0
Immunosuppressive Agents
0
mineral trioxide aggregate
0
Silicates
0
Calcium Compounds
0
Calcium Hydroxide
PF5DZW74VN
Aluminum Compounds
0
Drug Combinations
0
Pulp Capping and Pulpectomy Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1614-1624Déclaration de conflit d'intérêts
The authors declare no conflicts of interest to report.