Antibacterial activity of Bajakah Kalalawit phenolic against Staphylococcus aureus and possible use of phenolic nanoparticles.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
26 08 2024
Historique:
received: 23 04 2024
accepted: 21 08 2024
medline: 26 8 2024
pubmed: 26 8 2024
entrez: 25 8 2024
Statut: epublish

Résumé

Dayak tribes indigenous to the Indonesian island of Borneo has been using Bajakah Kalalawit (Uncaria gambir Roxb.) as traditional medicine for ages. This inspired us to develop phenolic from Bajakah Kalalawit extract as antibacterial agent. The extraction was done through decoction method and the determination of phenolic concentration was done using a visible spectrophotometer and Folin-Ciocalteu reagent (mixture of phosphotungstic and phosphomolybdic acids). We investigated the possibility of developing phenolic nanoparticle for future work. Kirby-Bauer method was used to assess antibacterial activity of phenolic against Staphylococcus aureus and the results were compared to Chloramphenicol in terms of its efficacy and duration of inhibition. This study contributes to the ongoing effort to address antibiotic resistance through the development of innovative antibacterial agents derived from natural sources. The results provide valuable insights into the potential of Bajakah Kalalawit phenolic extracts as a promising avenue for combating bacterial infections in the future.

Identifiants

pubmed: 39183360
doi: 10.1038/s41598-024-70799-4
pii: 10.1038/s41598-024-70799-4
doi:

Substances chimiques

Anti-Bacterial Agents 0
Plant Extracts 0
Phenols 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

19734

Informations de copyright

© 2024. The Author(s).

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Auteurs

S Suparno (S)

FMIPA, Universitas Negeri Yogyakarta, Yogyakarta, Indonesia. suparno_mipa@uny.ac.id.

E S Ayu Lestari (ES)

Faculty of Mathematics and Science, Bandung Institute of Technology, Bandung, Indonesia.

D Grace (D)

FMIPA, Universitas Negeri Yogyakarta, Yogyakarta, Indonesia.

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