AT1b receptors contribute to regional disparities in angiotensin II mediated aortic remodelling in mice.
aorta
hypertension
inflammation
remodelling
sex
stiffness
Journal
Journal of the Royal Society, Interface
ISSN: 1742-5662
Titre abrégé: J R Soc Interface
Pays: England
ID NLM: 101217269
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
medline:
28
8
2024
pubmed:
28
8
2024
entrez:
28
8
2024
Statut:
ppublish
Résumé
The renin-angiotensin system plays a key role in regulating blood pressure, which has motivated many investigations of associated mouse models of hypertensive arterial remodelling. Such studies typically focus on histological and cell biological changes, not wall mechanics. This study explores tissue-level ramifications of chronic angiotensin II infusion in wild-type (WT) and type 1b angiotensin II (AngII) receptor null (
Identifiants
pubmed: 39192727
doi: 10.1098/rsif.2024.0110
doi:
Substances chimiques
Angiotensin II
11128-99-7
Receptor, Angiotensin, Type 1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20240110Subventions
Organisme : HORIZON EUROPE European Innovation Council
Organisme : Agence Nationale de la Recherche
Organisme : NIH HHS
Pays : United States
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek