A New Renieramycin T Right-Half Analog as a Small Molecule Degrader of STAT3.

STAT3 Transcription Factor / metabolism Humans Cell Line, Tumor Structure-Activity Relationship Antineoplastic Agents / pharmacology Molecular Docking Simulation Epithelial-Mesenchymal Transition / drug effects Cell Movement / drug effects Aquatic Organisms
EMT NSCLC STAT3 degradation molecular docking renieramycin derivatives structure–activity relationship synthesis

Journal

Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729

Informations de publication

Date de publication:
14 Aug 2024
Historique:
received: 23 07 2024
revised: 09 08 2024
accepted: 12 08 2024
medline: 28 8 2024
pubmed: 28 8 2024
entrez: 28 8 2024
Statut: epublish

Résumé

Constitutive activation of STAT3 contributes to tumor development and metastasis, making it a promising target for cancer therapy. (1R,4R,5S)-10-hydroxy-9-methoxy-8,11-dimethyl-3-(naphthalen-2-ylmethyl)-1,2,3,4,5,6-hexahydro-1,5-epiminobenzo[d]azocine-4-carbonitrile, DH_31, a new derivative of the marine natural product Renieramycin T, showed potent activity against H292 and H460 cells, with IC

Identifiants

DOI: 10.3390/md22080370 PMID: 39195486
pubmed: 39195486
pii: md22080370
doi: 10.3390/md22080370
pii:
doi:

Substances chimiques

STAT3 Transcription Factor 0
STAT3 protein, human 0
Antineoplastic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Research Council of Thailand
ID : N42A670567

Auteurs

Preeyaphan Phookphan (P)

Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Satapat Racha (S)

Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Interdisciplinary Program in Pharmacology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.

Masashi Yokoya (M)

Department of Pharmaceutical Chemistry, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan.
ORCID: 0000-0003-0187-7595

Zin Zin Ei (ZZ)

Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
ORCID: 0000-0001-7906-0986

Daiki Hotta (D)

Department of Pharmaceutical Chemistry, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan.

Hongbin Zou (H)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Pithi Chanvorachote (P)

Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-3 › A New Renieramycin T Right-Half Analog as a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A New Renieramycin T Right-Half Analog as a...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › A New Renieramycin T Right-Half Analog as a...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › A New Renieramycin T Right-Half Analog as a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › A New Renieramycin T Right-Half Analog as a...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › A New Renieramycin T Right-Half Analog as a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Transition épithélio-mésenchymateuse › A New Renieramycin T Right-Half Analog as a...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › A New Renieramycin T Right-Half Analog as a...
questionsmedicales.fr › Phénomènes biologiques › Phénomènes écologiques et environnementaux › Eaux salées › Eau de mer › Organismes aquatiques › A New Renieramycin T Right-Half Analog as a...