Neurotoxins and Combination Therapies.
Humans
Botulinum Toxins, Type A
/ administration & dosage
Cosmetic Techniques
Skin Aging
/ drug effects
Combined Modality Therapy
/ methods
Rejuvenation
Dermal Fillers
/ administration & dosage
Face
Neuromuscular Agents
/ administration & dosage
Laser Therapy
/ methods
Patient Satisfaction
Neurotoxins
/ therapeutic use
Journal
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
ISSN: 1524-4725
Titre abrégé: Dermatol Surg
Pays: United States
ID NLM: 9504371
Informations de publication
Date de publication:
01 Sep 2024
01 Sep 2024
Historique:
medline:
29
8
2024
pubmed:
29
8
2024
entrez:
28
8
2024
Statut:
ppublish
Résumé
Facial aging involves multilevel changes, extending from the skin to deep support structures. A comprehensive treatment approach targeting the many aspects of facial dynamics and architecture is often necessary to achieve optimal correction, prevent changes before they occur, and/or help highlight inherited features. To explore the integration of botulinum toxin type A (BoNT-A) into multimodal aesthetic treatment plans. This article reviews evidence supporting the combination of BoNT-A with other minimally invasive cosmetic therapies, including dermal fillers, lasers, and energy-based devices as well as with plastic and reconstructive surgeries for more controlled healing and improved scar cosmesis. Combination treatment protocols including BoNT-A demonstrate higher patient satisfaction and retention rates compared to monotherapy or sequential treatments. Some guidelines for sequencing of treatments exist, but evidence is scant with certain combinations. Integrating BoNT-A into a larger aesthetic treatment plan is crucial for achieving natural and satisfying results in facial rejuvenation. Evidence supports better outcomes when incorporating with both surgical and nonsurgical modalities. Understanding how to address anatomy over time through different aesthetic therapies together allows for individually tailored, more deeply impactful treatment plans.
Sections du résumé
BACKGROUND
BACKGROUND
Facial aging involves multilevel changes, extending from the skin to deep support structures. A comprehensive treatment approach targeting the many aspects of facial dynamics and architecture is often necessary to achieve optimal correction, prevent changes before they occur, and/or help highlight inherited features.
OBJECTIVE
OBJECTIVE
To explore the integration of botulinum toxin type A (BoNT-A) into multimodal aesthetic treatment plans.
MATERIALS AND METHODS
METHODS
This article reviews evidence supporting the combination of BoNT-A with other minimally invasive cosmetic therapies, including dermal fillers, lasers, and energy-based devices as well as with plastic and reconstructive surgeries for more controlled healing and improved scar cosmesis.
RESULTS
RESULTS
Combination treatment protocols including BoNT-A demonstrate higher patient satisfaction and retention rates compared to monotherapy or sequential treatments. Some guidelines for sequencing of treatments exist, but evidence is scant with certain combinations.
CONCLUSION
CONCLUSIONS
Integrating BoNT-A into a larger aesthetic treatment plan is crucial for achieving natural and satisfying results in facial rejuvenation. Evidence supports better outcomes when incorporating with both surgical and nonsurgical modalities. Understanding how to address anatomy over time through different aesthetic therapies together allows for individually tailored, more deeply impactful treatment plans.
Identifiants
pubmed: 39196840
doi: 10.1097/DSS.0000000000004359
pii: 00042728-202409001-00018
doi:
Substances chimiques
Botulinum Toxins, Type A
EC 3.4.24.69
Dermal Fillers
0
Neuromuscular Agents
0
Neurotoxins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
S85-S90Informations de copyright
Copyright © 2024 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
Références
2022 ASPS procedural statistics release. Plast Reconstr Surg. 2014;153:1–24.
Carruthers J, Burgess C, Day D, Fabi SG, et al. Consensus recommendations for combined aesthetic interventions in the face using botulinum toxin, fillers, and energy-based devices. Dermatol Surg 2016;42:586–97.
Jones DH, Fitzgerald R, Cox SE, Butterwick K, et al. Preventing and treating adverse events of injectable fillers: evidence-based recommendations from the American Society for Dermatologic Surgery Multidisciplinary Task Force. Dermatol Surg 2021;47:214–26.
Kim JH, Park ES, Nam SM, Choi CY. Comparison of effectiveness and safety of a botulinum toxin monotherapy and a combination therapy with hyaluronic acid filler for improving glabellar frown. Aesthetic Plast Surg 2022;46:1872–80.
Carruthers J, Carruthers A. A multimodal approach to rejuvenation of the lower face. Dermatol Surg 2016;42:S89–93.
Levy PM. The ‘Nefertiti lift’: a new technique for specific re-contouring of the jawline. J Cosmet Laser Ther 2007;9:249–52.
Cartier H, Hedén P, Delmar H, Bergentz P, et al. Repeated full-face aesthetic combination treatment with AbobotulinumtoxinA, hyaluronic acid filler, and skin-boosting hyaluronic acid after monotherapy with AbobotulinumtoxinA or hyaluronic acid filler. Dermatol Surg 2020;46:475–82.
Chan K, Singh P, Dhar S, Mutsago T, et al. Botulinum A toxin and laser therapy: evidence and recommendations for combination treatment. Aesthet Surg J 2023;43:NP811–14.
Zimbler MS, Holds JB, Kokoska MS, Glaser DA, et al. Effect of botulinum toxin pretreatment on laser resurfacing results: a prospective, randomized, blinded trial. Arch Facial Plast Surg 2001;3:165–9.
Yamauchi PS, Lask G, Lowe NJ. Botulinum toxin type A gives adjunctive benefit to periorbital laser resurfacing. J Cosmet Laser Ther 2004;6:145–8.
Pomerantz H, Akintilo L, Shaw K, Lederhandler M, et al. Safety profile of combined same-day treatment for botulinum toxin with full face nonablative fractionated laser resurfacing. Dermatol Surg 2021;47:500–3.
Mahmoud BH, Burnett C, Ozog D. Prospective randomized controlled study to determine the effect of topical application of botulinum toxin A for crow's feet after treatment with ablative fractional CO2 laser. Dermatol Surg 2015;41:S75–81.
Fan X, Yin Y, Wang S, Li T, et al. Clinical assessment of the safety and effectiveness of nonablative fractional laser combined with transdermal delivery of botulinum toxin A in treating periocular wrinkles. Plast Reconstr Surg Glob Open 2016;4:e1004.
He G, Yang Q, Wu J, Huang Y, et al. Treating rosacea with botulism toxin: protocol for a systematic review and meta-analysis. J Cosmet Dermatol 2024;23:44–61.
Al-Niaimi F, Glagoleva E, Araviiskaia E. Pulsed dye laser followed by intradermal botulinum toxin type-A in the treatment of rosacea-associated erythema and flushing. Dermatol Ther 2020;33:e13976.
Carruthers J, Carruthers A. The effect of full-face broadband light treatments alone and in combination with bilateral crow's feet botulinum toxin type A chemodenervation. Dermatol Surg 2004;30:355–66.
Khoury JG, Saluja R, Goldman MP. The effect of botulinum toxin type A on full-face intense pulsed light treatment: a randomized, double-blind, split-face study. Dermatol Surg 2008;34:1062–9.
Carruthers J, Carruthers A. Adjunctive botulinum toxin type A: fillers and light-based therapies. Int Ophthalmol Clin 2005;45:143–51.
Bertossi D, Giampaoli G, Lucchese A, Manuelli M, et al. The skin rejuvenation associated treatment-Fraxel laser, Microbotox, and low G prime hyaluronic acid: preliminary results. Lasers Med Sci 2019;34:1449–55.
Turco P, Conforti C, D'andrea F, La Padula S. Carbon-assisted Q-switched Nd:YAG laser and microneedling delivery of botulinum toxin: a prospective pilot study. Plast Reconstr Surg 2024.
Fabi SG. Microfocused ultrasound with visualization for skin tightening and lifting: my experience and a review of the literature. Dermatol Surg 2014;40:S164–7.
Fabi SG. Noninvasive skin tightening: focus on new ultrasound techniques. Clin Cosmet Investig Dermatol 2015;8:47–52.
Alam M, White LE, Martin N, Witherspoon J, et al. Ultrasound tightening of facial and neck skin: a rater-blinded prospective cohort study. J Am Acad Dermatol 2010;62:262–9.
Fabi SG, Goldman MP, Mills DC, Werschler WP, et al. Combining microfocused ultrasound with botulinum toxin and temporary and semi-permanent dermal fillers: safety and current use. Dermatol Surg 2016;42:S168–76.
Cuerda-Galindo E, Palomar-Gallego MA, Linares-Garcíavaldecasas R. Are combined same-day treatments the future for photorejuvenation? Review of the literature on combined treatments with lasers, intense pulsed light, radiofrequency, botulinum toxin, and fillers for rejuvenation. J Cosmet Laser Ther 2015;17:49–54.
Wang JV, Valiga A, Albornoz CA, Geronemus RG. Safety of combining cosmetic injectables with radiofrequency microneedling: a 4.5-year review. J Cosmet Dermatol 2021;20:1084–5.
Semchyshyn NL, Kilmer SL. Does laser inactivate botulinum toxin? Dermatol Surg 2005;31:399–404.
Naik MN, Honavar SG, Das S, Desai S, et al. Blepharoplasty: an overview. J Cutan Aesthet Surg 2009;2:6–11.
Sweis IE, Hwang L, Cohen M. Preoperative use of neuromodulators to optimize surgical outcomes in upper blepharoplasty and brow lift. Aesthet Surg J 2018;38:941–8.
Huang YL, Wallace CG, Hsiao YC, Lee MC, et al. Botulinum toxin to improve lower blepharoplasty scar: a double-blinded, randomized, vehicle-controlled clinical trial. Aesthet Surg J 2021;41:1003–10.
Mendoza-Geng A, Gonzales-Medina K, Meza-Mauricio J, Muniz FWMG, et al. Clinical efficacy of lip repositioning technique and its modifications for the treatment of gummy smile: systematic review and meta-analysis. Clin Oral Investig 2022;26:4243–61.
Queiroz TP, Luvizuto ER, Marques DO, Santos VBP, et al. Botulinum toxin injections as an adjunct to surgical lip repositioning for gummy smile treatment. J Craniofac Surg 2022;33:e728–33.
Fatani B. An approach for gummy smile treatment using botulinum toxin A: a narrative review of the literature. Cureus 2023;15:e34032.
Adel N. Botulinum toxins and lip repositioning surgery with repeated botulinum toxin injection: a combined approach for gummy smile treatment. Plast Reconstr Surg Glob Open 2023;11:e5198.
Hammoudeh ZS, Stevens WG. Nonsurgical adjuncts following facelift to achieve optimal aesthetic outcomes: “icing on the cake”. Clin Plast Surg 2019;46:613–23.
Clark RP, Berris CE. Botulinum toxin: a treatment for facial asymmetry caused by facial nerve paralysis. Plast Reconstr Surg 1989;84:353–5.
Salles AG, Mota WM, Remigio AFDN, de Andrade ACH, et al. Management of post-facelift facial paralysis with botulinum toxin type A. Aesthet Surg J 2022;42:NP144–150.
Rohrich RJ, Savetsky IL, Cohen JM, Avashia YJ. Effective treatment of platysma bands with neurotoxin. Plast Reconstr Surg Glob Open 2020;8:e2812.
Sinclair NR, Kochuba A, Coombs DM, Couto RA, et al. Face lift practice patterns: an American Society of Plastic Surgeons member survey, 2000 and 2020. How much have we changed? Plast Reconstr Surg 2022;149:1096e–105e.
Rohrich RJ, Sinno S, Vaca EE. Getting better results in facelifting. Plast Reconstr Surg Glob Open 2019;7:e2270.
Narasimhan K, Ramanadham S, O'Reilly E, Rohrich RJ. Secondary neck lift and the importance of midline platysmaplasty: review of 101 cases. Plast Reconstr Surg 2016;137:667e–75e.
Flynn TC. Use of intraoperative botulinum toxin in facial reconstruction. Dermatol Surg 2009;35:182–8.
DePry JL, Mann M. Successful treatment of postoperative pain after Mohs micrographic surgery with onabotulinum toxin A. Dermatol Surg 2017;43:1491–4.
El Shaer WM, Ahmed AEE, Sakr WM, Hawas EM, et al. Effect of perivascular injection of botulinum toxin type A versus lidocaine in survival of random pattern flaps in a rat model. Plast Reconstr Surg 2019;143:527e–33e.
Hu L, Zou Y, Chang SJ, Qiu Y, et al. Effects of botulinum toxin on improving facial surgical scars: a prospective, split-scar, double-blind, randomized controlled trial. Plast Reconstr Surg 2018;141:646–50.
Lee SH, Min HJ, Kim YW, Cheon YW. The efficacy and safety of early postoperative botulinum toxin A injection for facial scars. Aesthetic Plast Surg 2018;42:530–7.
Chen S, Yang Y, Zhang D, Liu Y, et al. Local injection of botulinum toxin type A to prevent postoperative scar. J Craniofac Surg 2020;31:440–3.
Qiao Z, Yang H, Jin L, Li S, et al. The efficacy and safety of botulinum toxin injections in preventing postoperative scars and improving scar quality: a systematic review and meta-analysis. Aesthetic Plast Surg 2021;45:2350–62.
Li MY, Chiu WK, Wang HJ, Chen IF, et al. Effectiveness of botulinum toxin type A injection on scars: a systematic review and meta-analysis of randomized controlled trials. Plast Reconstr Surg 2022;150:1249e–58e.
Gregory A, Humphrey S, Chunharas C, Ogilvie P, et al. Retention rates among patients undergoing multimodal facial rejuvenation treatment versus a single monotherapy in cosmetic dermatology practices. Dermatol Surg 2020;46:240–6.