Physical Activity and Epigenetic Aging in Breast Cancer Treatment.
DNA methylation
epigenetic clock
exercise
telomere
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Aug 2024
06 Aug 2024
Historique:
received:
10
07
2024
revised:
01
08
2024
accepted:
05
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
Biological age, reflecting the cumulative damage in the body over a lifespan, is a dynamic measure more indicative of individual health than chronological age. Accelerated aging, when biological age surpasses chronological age, is implicated in poorer clinical outcomes, especially for breast cancer (BC) survivors undergoing treatments. This preliminary study investigates the impact of a 16-week online supervised physical activity (PA) intervention on biological age in post-surgery female BC patients. Telomere length was measured using qPCR, and the ELOVL2-based epigenetic clock was assessed via DNA methylation pyrosequencing of the
Identifiants
pubmed: 39201283
pii: ijms25168596
doi: 10.3390/ijms25168596
pii:
doi:
Substances chimiques
Fatty Acid Elongases
EC 2.3.1.-
ELOVL2 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MUR Italy
ID : PNR 2021-2027, DM n. 737 del 25-06-2021
Organisme : CREATEC-CV grant cofounding by IVACE (Valencian region) and FEDER (European Union)
ID : IMCBTA/2018/29