Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study.
Humans
Male
Female
Middle Aged
Adrenal Gland Neoplasms
/ genetics
Adult
Pheochromocytoma
/ genetics
Mitochondrial Proteins
/ genetics
Gene Expression Regulation, Neoplastic
Aged
Adrenocortical Adenoma
/ genetics
RNA, Messenger
/ genetics
Adrenocortical Carcinoma
/ genetics
Biomarkers, Tumor
/ genetics
MOTS-c
adrenal tumors
mitochondria homeostasis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Aug 2024
09 Aug 2024
Historique:
received:
30
06
2024
revised:
07
08
2024
accepted:
08
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
Adrenal tumors, such as adrenocortical carcinoma (ACC), adrenocortical adenoma (ACA), and pheochromocytoma (PCC) are complex diseases with unclear causes and treatments. Mitochondria and mitochondrial-derived peptides (MDPs) are crucial for cancer cell survival. The primary aim of this study was to analyze samples from different adrenal diseases, adrenocortical carcinoma, adrenocortical adenoma, and pheochromocytoma, and compare them with normal adrenal tissue to determine whether the expression levels of the mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) gene and protein vary between different types of adrenal tumors compared to healthy controls using qPCR, ELISA, and IHC methods. Results showed decreased
Identifiants
pubmed: 39201408
pii: ijms25168721
doi: 10.3390/ijms25168721
pii:
doi:
Substances chimiques
MOTS-c peptide, human
0
Mitochondrial Proteins
0
RNA, Messenger
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Centre in Poland
ID : 2020/38/E/NZ4/00020
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.