Precision Medicine in Childhood Cancer: The Influence of Genetic Polymorphisms on Vincristine-Induced Peripheral Neuropathy.
Humans
Vincristine
/ adverse effects
Peripheral Nervous System Diseases
/ chemically induced
Polymorphism, Single Nucleotide
Child
Female
Male
Multidrug Resistance-Associated Proteins
/ genetics
Multidrug Resistance-Associated Protein 2
Child, Preschool
Precision Medicine
/ methods
Neoplasms
/ drug therapy
Adolescent
Retrospective Studies
Cell Cycle Proteins
/ genetics
Infant
Antineoplastic Agents, Phytogenic
/ adverse effects
Genetic Predisposition to Disease
Genotype
Alleles
ATP Binding Cassette Transporter, Subfamily B
/ genetics
Microtubule-Associated Proteins
pediatric oncology
peripheral neuropathy
pharmacogenetics
precision medicine
toxicity
vincristine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Aug 2024
13 Aug 2024
Historique:
received:
23
07
2024
revised:
08
08
2024
accepted:
12
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
Cancer is the leading cause of disease-related death among children. Vincristine (VCR), a key component of childhood cancer treatment protocols, is associated with the risk of peripheral neuropathy (PN), a condition that may be reversible upon drug discontinuation but can also leave lasting sequelae. Single nucleotide polymorphism (SNP) in genes involved in VCR pharmacokinetics and pharmacodynamics have been investigated in relation to an increased risk of PN. However, the results of these studies have been inconsistent. A retrospective cohort study was conducted to investigate the potential association of drug transporter genes from the ATP-binding cassette (
Identifiants
pubmed: 39201483
pii: ijms25168797
doi: 10.3390/ijms25168797
pii:
doi:
Substances chimiques
Vincristine
5J49Q6B70F
Multidrug Resistance-Associated Proteins
0
ABCC2 protein, human
0
Multidrug Resistance-Associated Protein 2
0
CEP72 protein, human
0
multidrug resistance-associated protein 1
Y49M64GZ4Q
Cell Cycle Proteins
0
Antineoplastic Agents, Phytogenic
0
ABCB1 protein, human
0
ATP Binding Cassette Transporter, Subfamily B
0
Microtubule-Associated Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PT13/0010/0039