Intermediate filaments at a glance.

Intermediate Filaments / metabolism Humans Animals Intermediate Filament Proteins / metabolism Signal Transduction Cytoskeleton / metabolism
Cell fate Classification and function Cytoskeleton Disease Intermediate filaments Structure

Journal

Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457

Informations de publication

Date de publication:
15 Aug 2024
Historique:
medline: 1 9 2024
pubmed: 31 8 2024
entrez: 29 8 2024
Statut: ppublish

Résumé

Intermediate filaments (IFs) comprise a large family of versatile cytoskeletal proteins, divided into six subtypes with tissue-specific expression patterns. IFs have a wide repertoire of cellular functions, including providing structural support to cells, as well as active roles in mechanical support and signaling pathways. Consequently, defects in IFs are associated with more than 100 diseases. In this Cell Science at a Glance article, we discuss the established classes of IFs and their general features, their functions beyond structural support, and recent advances in the field. We also highlight their involvement in disease and potential use as clinical markers of pathological conditions. Finally, we provide our view on current knowledge gaps and the future directions of the IF field.

Identifiants

DOI: 10.1242/jcs.261386 PMID: 39206824
pubmed: 39206824
pii: 361810
doi: 10.1242/jcs.261386
pii:
doi:

Substances chimiques

Intermediate Filament Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Academy of Finland
Organisme : Sigrid Jusélius Foundation
Organisme : Jane and Aatos Erkko Foundation
Organisme : Magnus Ehrnrooth Foundation
Organisme : K. Albin Johanssons Stiftelse
Organisme : Otto A. Malm Foundation
Organisme : Finnish Cultural Foundation
Organisme : Swedish Cultural Foundation
Organisme : Ella and Georg Ehrnrooth Foundation
Organisme : Emil Altonen
Organisme : Instrumentarium Science Foundation
Organisme : Swiss National Science Foundation
ID : SNSF 310030_207453
Pays : Switzerland

Informations de copyright

© 2024. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interests The authors declare no competing or financial interests.

Auteurs

Leila S Coelho-Rato (LS)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, 20520 Turku, Finland.
ORCID: 0000-0002-1584-5415

Sepideh Parvanian (S)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, 20520 Turku, Finland.
Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA.
ORCID: 0000-0002-3884-9961

Sarka Andrs Salajkova (S)

Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Ohad Medalia (O)

Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

John E Eriksson (JE)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, 20520 Turku, Finland.
Euro-Bioimaging ERIC, 20520 Turku, Finland.
ORCID: 0000-0002-1570-7725

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Filaments intermédiaires › Intermediate filaments at a glance.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Intermediate filaments at a glance.
questionsmedicales.fr › Eucaryotes › Animaux › Intermediate filaments at a glance.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Intermediate filaments at a glance.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Intermediate filaments at a glance.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Intermediate filaments at a glance.