Harnessing Nitric Oxide-Donating Benzofuroxans for Targeted Inhibition of Carbonic Anhydrase IX in Cancer.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
29 Aug 2024
Historique:
medline: 31 8 2024
pubmed: 31 8 2024
entrez: 29 8 2024
Statut: aheadofprint

Résumé

We describe here the design and antitumor evaluation of benzofuroxan-based nitric oxide (NO)-donor hybrid derivatives targeting human carbonic anhydrases (hCAs) IX and XII. The most effective compounds,

Identifiants

DOI: 10.1021/acs.jmedchem.4c01563 PMID: 39207927
pubmed: 39207927
doi: 10.1021/acs.jmedchem.4c01563
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Silvia Bua (S)

NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Firenze Italy.

Alessio Nocentini (A)

NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Firenze Italy.
ORCID: 0000-0003-3342-702X

Alessandro Bonardi (A)

NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Firenze Italy.

Giuseppe Palma (G)

Experimental Animal Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli 80131, Italy.

Giulia Ciampi (G)

Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli″, Napoli 80138, Italy.

Angela Giliberti (A)

Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli″, Napoli 80138, Italy.

Federica Iannelli (F)

Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS -Fondazione G. Pascale, Napoli 80131, Italy.

Francesca Bruzzese (F)

Experimental Animal Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli 80131, Italy.

Claudiu T Supuran (CT)

NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Firenze Italy.
ORCID: 0000-0003-4262-0323

Filomena de Nigris (F)

Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli″, Napoli 80138, Italy.

Classifications MeSH