Influence of selection on the probability of fixation at a locus with multiple alleles.
Diffusion analysis
Nearly neutral alleles
Random genetic drift
Selective effect
Stochastic population dynamics
Journal
BMC genomics
ISSN: 1471-2164
Titre abrégé: BMC Genomics
Pays: England
ID NLM: 100965258
Informations de publication
Date de publication:
30 Aug 2024
30 Aug 2024
Historique:
received:
09
04
2024
accepted:
22
08
2024
medline:
1
9
2024
pubmed:
1
9
2024
entrez:
30
8
2024
Statut:
epublish
Résumé
Genes exist in a population in a variety of forms (alleles), as a consequence of multiple mutation events that have arisen over the course of time. In this work we consider a locus that is subject to either multiplicative or additive selection, and has n alleles, where n can take the values 2, 3, 4, We determined the fixation probability when all terms up to second order in the We have analytically exposed the leading way the probability of fixation, at a locus with multiple alleles, is affected by selection. This result may offer important insights into CDCV traits that have extreme phenotypic variance due to numerous, low-penetrance susceptibility alleles.
Sections du résumé
BACKGROUND
BACKGROUND
Genes exist in a population in a variety of forms (alleles), as a consequence of multiple mutation events that have arisen over the course of time. In this work we consider a locus that is subject to either multiplicative or additive selection, and has n alleles, where n can take the values 2, 3, 4,
RESULTS
RESULTS
We determined the fixation probability when all terms up to second order in the
CONCLUSIONS
CONCLUSIONS
We have analytically exposed the leading way the probability of fixation, at a locus with multiple alleles, is affected by selection. This result may offer important insights into CDCV traits that have extreme phenotypic variance due to numerous, low-penetrance susceptibility alleles.
Identifiants
pubmed: 39215209
doi: 10.1186/s12864-024-10733-0
pii: 10.1186/s12864-024-10733-0
pmc: PMC11365252
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
819Informations de copyright
© 2024. The Author(s).
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