Correlation of serum thyrotropin and thyroid hormone levels with diabetic kidney disease: a cross-sectional study.
Humans
Male
Cross-Sectional Studies
Female
Middle Aged
Thyrotropin
/ blood
Diabetes Mellitus, Type 2
/ blood
Diabetic Nephropathies
/ blood
Glomerular Filtration Rate
Aged
Thyroid Hormones
/ blood
Biomarkers
/ blood
Prognosis
Thyroxine
/ blood
Triiodothyronine
/ blood
Thyroid Function Tests
Albuminuria
/ blood
Adult
Diabetic kidney disease
Hypothyroidism
Thyroid hormone
Thyrotropin
Journal
BMC endocrine disorders
ISSN: 1472-6823
Titre abrégé: BMC Endocr Disord
Pays: England
ID NLM: 101088676
Informations de publication
Date de publication:
30 Aug 2024
30 Aug 2024
Historique:
received:
20
02
2024
accepted:
21
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
30
8
2024
Statut:
epublish
Résumé
The relationship between thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4) and diabetic kidney disease (DKD) is still controversial, and this study analyzed the correlation between TSH, FT3, FT4 and DKD in patients with type 2 diabetes mellitus (T2DM). T2DM patients (1216) were divided into five groups based on serum TSH, FT3, and FT4 levels, differences in urinary albumin excretion rate (UACR), estimated glomerular filtration rate (eGFR) were compared. Binary logistic regression verified independent correlations among TSH, FT3, FT4 and UACR, eGFR. TSH and FT3 predictive values for DKD were analyzed using receiver operating characteristic (ROC) curves. The prevalence of albuminuria with decreased eGFR was higher in T2DM patients with subclinical hypothyroidism and overt hypothyroidism than that in patients with normal thyroid function. TSH positively correlated with UACR (r = 0.133, p < 0.001) and positively correlated with eGFR (r = -0.218, p < 0.001), FT3 negatively correlated with UACR (r = -0.260, p < 0.001) and positively correlated with eGFR (r = 0.324, p < 0.001). With the change from the lower normal level to the increased level of TSH and the change from the higher normal level to the reduced level of FT3, the prevalence of albuminuria gradually increased, the prevalence of decreased eGFR gradually increased in TSH groups and FT3 groups. After adjusting for age, BMI, duration of diabetes, TPOAb, TGAb, smoking, drinking, hypertension, the use of anti-diabetic medications (metformin, sodium-glucose cotransporter 2 inhibitors), HbA1c, CRP, TC, TG, LDL-C, and HDL-C, both TSH and FT3 correlated with increased UACR (TSH: OR 1.253, p = 0.001; FT3: OR 0.166, p < 0.001) and decreased eGFR (TSH: OR 1.245, p < 0.001, FT3: OR 0.579, p < 0.001), but this correlation of TSH with eGFR < 60 mL/min/1.73 m Increased TSH and reduced FT3 levels were associated with DKD in T2DM patients, but in a sex-dependent manner. FT3 had a higher predictive value for DKD.
Identifiants
pubmed: 39215277
doi: 10.1186/s12902-024-01699-x
pii: 10.1186/s12902-024-01699-x
pmc: PMC11363369
doi:
Substances chimiques
Thyrotropin
9002-71-5
Thyroid Hormones
0
Biomarkers
0
Thyroxine
Q51BO43MG4
Triiodothyronine
06LU7C9H1V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
170Subventions
Organisme : Lanzhou Science and Technology Bureau
ID : 2022-3-46
Organisme : National Natural Science Foundation of China
ID : NO.82360161
Informations de copyright
© 2024. The Author(s).
Références
Diabetes Metab J. 2022 Mar;46(2):239-256
pubmed: 35385635
Nat Rev Nephrol. 2013 Oct;9(10):599-609
pubmed: 23999398
J Clin Endocrinol Metab. 2006 Jun;91(6):2126-32
pubmed: 16537677
Nephrol Dial Transplant. 2019 Apr 1;34(4):650-659
pubmed: 29684213
Endocr J. 2014;61(10):1011-8
pubmed: 25100149
Int Urol Nephrol. 2018 Jan;50(1):97-103
pubmed: 29196928
Diabetes Care. 2023 Jan 1;46(Suppl 1):S191-S202
pubmed: 36507634
BMC Med. 2016 Sep 30;14(1):150
pubmed: 27686165
BMC Endocr Disord. 2023 Mar 8;23(1):56
pubmed: 36882783
J Physiol Anthropol. 2021 Oct 9;40(1):15
pubmed: 34627373
Nephrology (Carlton). 2017 Oct;22(10):790-795
pubmed: 27412074
PLoS One. 2015 Aug 13;10(8):e0135233
pubmed: 26270348
J Am Coll Cardiol. 2005 Feb 1;45(3):439-45
pubmed: 15680725
Int J Epidemiol. 2014 Oct;43(5):1624-32
pubmed: 25011453
J Am Soc Nephrol. 2012 Jan;23(1):22-6
pubmed: 22021708
Eur J Endocrinol. 2006 Feb;154(2):197-212
pubmed: 16452532
Int J Gen Med. 2022 Dec 19;15:8659-8668
pubmed: 36568840
Ren Fail. 2005;27(6):739-42
pubmed: 16350827
Br J Clin Pharmacol. 2018 Sep;84(9):2120-2128
pubmed: 29791023
Endocr J. 2023 Jul 28;70(7):687-696
pubmed: 37081693
Diabetes Res Clin Pract. 2011 Dec;94(3):e75-7
pubmed: 21925759
Nephron. 2019;142(2):91-97
pubmed: 30799424
Thyroid Res. 2012 Jan 26;5(1):1
pubmed: 22280879
Curr Med Res Opin. 2015 Dec;31(12):2233-40
pubmed: 26366481
Curr Vasc Pharmacol. 2020;18(2):117-124
pubmed: 31057114
Nat Rev Nephrol. 2018 Mar;14(3):151-164
pubmed: 29355169
Am J Physiol Renal Physiol. 2005 Oct;289(4):F672-8
pubmed: 15914774
Kidney Blood Press Res. 2018;43(4):1121-1130
pubmed: 30016786
Front Endocrinol (Lausanne). 2019 Jul 04;10:440
pubmed: 31333585
Br J Gen Pract. 2018 Feb;68(667):94-95
pubmed: 29371315
Sci Rep. 2018 Mar 16;8(1):4728
pubmed: 29549262
Kidney Int. 2022 Nov;102(5S):S1-S127
pubmed: 36272764
Endocr Res. 2012;37(3):110-6
pubmed: 22571510
Front Endocrinol (Lausanne). 2022 Sep 29;13:977355
pubmed: 36246924
Endocr Rev. 2019 Jun 1;40(3):789-824
pubmed: 30649221
Rev Endocr Metab Disord. 2017 Mar;18(1):131-144
pubmed: 27864708
J Endocrinol. 2002 Jul;174(1):121-5
pubmed: 12098670
J Diabetes Res. 2020 Mar 28;2020:4798947
pubmed: 32337292
Front Endocrinol (Lausanne). 2022 Dec 12;13:1064665
pubmed: 36578951
Eur J Endocrinol. 2011 Jan;164(1):101-5
pubmed: 20930062
Diabetes Res Clin Pract. 2022 Jan;183:109119
pubmed: 34879977
Clin Endocrinol (Oxf). 2011 Jul;75(1):1-9
pubmed: 21521298
Diabetes Metab J. 2015 Feb;39(1):66-73
pubmed: 25729715
J Transl Med. 2016 Dec 3;14(1):336
pubmed: 27914474
J Clin Endocrinol Metab. 2002 Feb;87(2):489-99
pubmed: 11836274
BMC Endocr Disord. 2023 Jul 10;23(1):146
pubmed: 37430240
Curr Opin Nephrol Hypertens. 2019 Mar;28(2):178-182
pubmed: 30652978