Comparison of the Ultrasonography Features of the Breast in Women with Fibroadenoma and Those with Other Breast Lumps.
Journal
The Nigerian postgraduate medical journal
ISSN: 1117-1936
Titre abrégé: Niger Postgrad Med J
Pays: Nigeria
ID NLM: 9613595
Informations de publication
Date de publication:
01 Jul 2024
01 Jul 2024
Historique:
received:
02
01
2024
accepted:
03
06
2024
medline:
2
9
2024
pubmed:
2
9
2024
entrez:
2
9
2024
Statut:
ppublish
Résumé
Fibroadenoma (FA) is documented as the most common benign breast disease typically presenting as a lump. A wide variety of other diseases including breast cancer can similarly present as lumps hence the need for further differentiation. Ultrasonography plays a vital role in the evaluation and treatment of breast lumps with histological analysis as the gold standard. This study compared the physical and sonographic features of the breast in women with FA and women with breast lumps due to other diseases. This is a single-centre comparative study. Clinical and sonographic breast evaluations of the recruited patients with lumps were done and reported using the American College of Radiology Breast Imaging Reporting and Data System score. The lumps were biopsied, and histological diagnosis was documented. Clinical and imaging features of the breasts of women with FA were then compared with those of women with lumps from other breast diseases, and collated data were analysed using SPSS Statistical version 23.0. Data from 118 subjects (59 in each group) were used for this study. There was a significant difference in the physical and sonographic appearance of FA concerning the patient's age, parity, change in lesion size, perilesional architecture, echogenicity, borders, capsule and background breast density. No FA was found in women with less dense breasts. The sonographic features of breasts showed some differences from the corresponding features of FA and other breast lesions. This has the potential to increase the efficiency of pre-operative diagnosis of FA and could be further applied in developing diagnostic criteria for FA in our environment.
Sections du résumé
BACKGROUND
BACKGROUND
Fibroadenoma (FA) is documented as the most common benign breast disease typically presenting as a lump. A wide variety of other diseases including breast cancer can similarly present as lumps hence the need for further differentiation. Ultrasonography plays a vital role in the evaluation and treatment of breast lumps with histological analysis as the gold standard.
OBJECTIVE
OBJECTIVE
This study compared the physical and sonographic features of the breast in women with FA and women with breast lumps due to other diseases.
MATERIALS AND METHODS
METHODS
This is a single-centre comparative study. Clinical and sonographic breast evaluations of the recruited patients with lumps were done and reported using the American College of Radiology Breast Imaging Reporting and Data System score. The lumps were biopsied, and histological diagnosis was documented. Clinical and imaging features of the breasts of women with FA were then compared with those of women with lumps from other breast diseases, and collated data were analysed using SPSS Statistical version 23.0.
RESULTS
RESULTS
Data from 118 subjects (59 in each group) were used for this study. There was a significant difference in the physical and sonographic appearance of FA concerning the patient's age, parity, change in lesion size, perilesional architecture, echogenicity, borders, capsule and background breast density. No FA was found in women with less dense breasts.
CONCLUSION
CONCLUSIONS
The sonographic features of breasts showed some differences from the corresponding features of FA and other breast lesions. This has the potential to increase the efficiency of pre-operative diagnosis of FA and could be further applied in developing diagnostic criteria for FA in our environment.
Identifiants
pubmed: 39219347
doi: 10.4103/npmj.npmj_3_24
pii: 00130415-202431030-00006
doi:
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
240-246Informations de copyright
Copyright © 2024 Copyright: © 2024 Nigerian Postgraduate Medical Journal.
Références
Sangma MB, Panda K, Dasiah S. A clinico-pathological study on benign breast diseases. J Clin Diagn Res 2013;7:503–6.
Uwaezuoke SC, Udoye EP. Benign breast lesions in Bayelsa state, Niger Delta Nigeria: A 5 year multicentre histopathological audit. Pan Afr Med J 2014;19:394.
Clegg-Lamptey JN, Baako BN, Badoe EA. The breast. In: Principles and Practice of Surgery Including Pathology in the Tropics. 4th ed. Ghana publishing corporation; p. 488–93.
Mashoori N, Assarian A, Zand S, Patocskai E. Recurrent multiple fibroadenomas: History of a case presented in MDT meeting with clinical discussion and decision making. Arch Breast Cancer 2018;5:159–62.
Nggada HA, Gali BM, Bakari AA, Yawe-Terna EH, Tahir MB, Apari E, et al. The spectrum offemale breast diseases among Nigerian population in Sahel climatic zone. J Med Med Sci 2011;2:1157–61.
Abhishek V, Ajitha MB, Shivaswamy BS, Srinivasan N. A systematic study on fibroadenoma of the breast. Eur J Surg Sci 2012;3:80–5.
Orr B, Kelley JL 3rd. Benign breast diseases: Evaluation and management. Clin Obstet Gynecol 2016;59:710–26.
Thakur B, Misra V. Clinicohistopathological features of fibroadenoma breast inpatients less than 20 years of age and its comparison with elder patients. IOSR J Nurs Health Sci 2014;3:67–71.
Peng Y, Xie F, Zhao Y, Wang S; Chinese Society of Breast Surgery. Clinical practice guideline for breast fibroadenoma: Chinese Society of Breast Surgery (CSBrS) practice guideline 2021. Chin Med J (Engl) 2021;134:1014–6.
Paepke S, Metz S, Brea Salvago A, Ohlinger R. Benign breast tumours – Diagnosis and management. Breast Care (Basel) 2018;13:403–12.
Taylor K, Lowes S, Stanley E, Hamilton P, Redman A, Leaver A, et al. Evidence for avoiding the biopsy of typical fibroadenomas in women aged 25-29 years. Clin Radiol 2019;74:676–81.
Zimmermann N, Ohlinger R. Diagnostic value of palpation, mammography, and ultrasonography in the diagnosis of fibroadenoma: Impact of breast density, patient age, ultrasonographic size, and palpability. Ultraschall Med 2012;33:E151–7.
Spak DA, Plaxco JS, Santiago L, Dryden MJ, Dogan BE. BI-RADS(®) fifth edition: A summary of changes. Diagn Interv Imaging 2017;98:179–90.
Olarinoye-Akorede SA, Farouk B, Liman AA, Kabir B. The sonographic spectrum of pathologically proven fibroadenoma of the breast among women in Zaria, Northern Nigeria. Trop J Health Sci 2018;25:51–6.
Dogan BE, Turnbull LW. Imaging of triple-negative breast cancer. Ann Oncol 2012;23 Suppl 6:i23–9.
Lee S, Mercado CL, Cangiarella JF, Chhor CM. Frequency and outcomes of biopsy-proven fibroadenomas recommended for surgical excision. Clin Imaging 2018;50:31–6.
Hubbard JL, Cagle K, Davis JW, Kaups KL, Kodama M. Criteria for excision of suspected fibroadenomas of the breast. Am J Surg 2015;209:297–301.
Greenberg R, Skornick Y, Kaplan O. Management of breast fibroadenomas. J Gen Intern Med 1998;13:640–5.
Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian J Psychol Med 2013;35:121–6.
Sperber F, Blank A, Metser U, Flusser G, Klausner JM, Lev-Chelouche D. Diagnosis and treatment of breast fibroadenomas by ultrasound-guided vacuum-assisted biopsy. Arch Surg 2003;138:796–800.
Mokhtari-Dizadji M, Vahed M, Gity M. The application of dicriminant analysis in the differentiation of fibroadenoma and ductal carcinoma of the breast tissue using ultrasound velocity measurement. Iran J Radiat Res 2003;1:163–9.
Olu-Eddo AN, Ugiagbe EE. Benign breast lesions in an African population: A 25-year histopathological review of 1864 cases. Niger Med J 2011;52:211–6.
Ochicha O, Edino S, Mohammed A, Amin S. Benign breast lesions in Kano. Niger J Surg Res 2002;4:1–5.
Duric N, Boyd N, Littrup P, Sak M, Myc L, Li C, et al. Breast density measurements with ultrasound tomography: A comparison with film and digital mammography. Med Phys 2013;40:013501.
Ghosh K, Vierkant RA, Frank RD, Winham S, Visscher DW, Pankratz VS, et al. Association between mammographic breast density and histologic features of benign breast disease. Breast Cancer Res 2017;19:134.
Yilmaz E, Sal S, Lebe B. Differentiation of phyllodes tumors versus fibroadenomas. Acta Radiol 2002;43:34–9.
Yoon GY, Cha JH, Kim HH, Shin HJ, Chae EY, Choi WJ. Sonographic features that can be used to differentiate between small triple-negative breast cancer and fibroadenoma. Ultrasonography 2018;37:149–56.
Namazi A, Adibi A, Haghighi M, Hashemi M. An evaluation of ultrasound features of breast fibroadenoma. Adv Biomed Res 2017;6:153.
Gokhale S. Ultrasound characterization of breast masses. Indian J Radiol Imaging 2009;19:242–7.
Chu B, Crystal P. Imaging of fibroepithelial lesions: A pictorial essay. Can Assoc Radiol J 2012;63:135–45.
Wiratkapun C, Piyapan P, Lertsithichai P, Larbcharoensub N. Fibroadenoma versus phyllodes tumor: Distinguishing factors in patients diagnosed with fibroepithelial lesions after a core needle biopsy. Diagn Interv Radiol 2014;20:27–33.
Stachs A, Stubert J, Reimer T, Hartmann S. Benign breast disease in women. Dtsch Arztebl Int 2019;116:565–74.
Moy L, Heller SL, Bailey L, D’Orsi C, DiFlorio RM, Green ED, et al. ACR appropriateness criteria® palpable breast masses. J Am Coll Radiol 2017;14:S203–24.
Royal College of Radiologists (Great Britain). Faculty of clinical radiology. Royal College of Radiologists; 2019. Available from: https://www.rcr.ac.uk/media/0dkh5y5d/rcr-publications_guidance-on-screening-and-symptomatic-breast-imaging-fourth-edition_november-2019.pdf. [Last assessed on 2024 Feb 13].
Khanbhai M, Borgen R, Dobrashian R. Ultrasound can accurately diagnose fibroadenoma in women less than 35 years. Int J Radiol Imaging Technol 2017;3:026.
Pandit P, Murkey SP, Agarwal A, Jaiswal A, Agrawal S. Understanding fibroadenoma of the breast: A comprehensive review of pre-operative and post-operative clinicopathological correlations. Cureus 2023;15:e51329.
Sheth M, Lodhi U, Chen B, Park Y, McElligott S. Initial institutional experience with cryoablation therapy for breast fibroadenomas: Technique, molecular science, and post-therapy imaging follow-up. J Ultrasound Med 2019;38:2769–76.
Brahmachari S, Bhagat V, Patil P, Vasuniya V. Evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia. J Pharm Bioallied Sci 2021;13:S1386–9.