Evaluating the accuracy of the MBT Lipid Xtract Kit for assessing colistin resistance in comparison to broth microdilution.

Colistin / pharmacology Microbial Sensitivity Tests Drug Resistance, Bacterial Anti-Bacterial Agents / pharmacology Humans Gram-Negative Bacteria / drug effects Whole Genome Sequencing Escherichia coli / drug effects
BMD colistin lipidomics mcr-1 resistance screening susceptibility testing

Journal

Journal of medical microbiology
ISSN: 1473-5644
Titre abrégé: J Med Microbiol
Pays: England
ID NLM: 0224131

Informations de publication

Date de publication:
Sep 2024
Historique:
medline: 2 9 2024
pubmed: 2 9 2024
entrez: 2 9 2024
Statut: ppublish

Résumé

Colistin resistance testing methods such as broth microdilution (BMD) are time-consuming and labour intensive for clinical laboratories. MBT Lipid Xtract Kit on MALDI Biotyper Sirius System (Bruker, Billerica, MA, USA) utilizes lipidomic analysis to identify specific cell wall modifications associated with colistin resistance. We compared MBT to BMD (ComASP Colistin, Liofilchem) across 36 Gram-negative isolates (non-resistant MIC ≤2 µg ml

Identifiants

DOI: 10.1099/jmm.0.001881 PMID: 39222340
pubmed: 39222340
doi: 10.1099/jmm.0.001881
doi:

Substances chimiques

Colistin Z67X93HJG1
Anti-Bacterial Agents 0

Types de publication

Journal Article Comparative Study Evaluation Study

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Calvin Ka-Fung Lo (CK)

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Gordon Ritchie (G)

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Division of Medical Microbiology and Virology, Providence Health Care, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Jennifer Bilawka (J)

Division of Medical Microbiology and Virology, Providence Health Care, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Leah Gowland (L)

Division of Medical Microbiology and Virology, Providence Health Care, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Samuel D Chorlton (SD)

BugSeq Bioinformatics, Vancouver, British Columbia, Canada.

Willson Jang (W)

Division of Medical Microbiology and Virology, Providence Health Care, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Nancy Matic (N)

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Division of Medical Microbiology and Virology, Providence Health Care, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Marc G Romney (MG)

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Division of Medical Microbiology and Virology, Providence Health Care, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Aleksandra Stefanovic (A)

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Division of Medical Microbiology and Virology, Providence Health Care, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Christopher F Lowe (CF)

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Division of Medical Microbiology and Virology, Providence Health Care, St. Paul's Hospital, Vancouver, British Columbia, Canada.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Polymyxines › Colistine › Evaluating the accuracy of the MBT Lipid...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Evaluating the accuracy of the MBT Lipid...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Evaluating the accuracy of the MBT Lipid...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Evaluating the accuracy of the MBT Lipid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evaluating the accuracy of the MBT Lipid...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Evaluating the accuracy of the MBT Lipid...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Evaluating the accuracy of the MBT Lipid...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Evaluating the accuracy of the MBT Lipid...