TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization.
TRP channels
corneal neuralgia
human mutation
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
10 Sep 2024
10 Sep 2024
Historique:
medline:
3
9
2024
pubmed:
3
9
2024
entrez:
3
9
2024
Statut:
ppublish
Résumé
The factors that contribute to pain after nerve injury remain incompletely understood. Laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) are common surgical techniques to correct refractive errors. After LASIK or PRK, a subset of patients suffers intense and persistent pain, of unknown origin, described by patients as feeling like shards of glass in their eye. Here, we evaluated a TRPV1 variant, p.V527M, found in a 49-y-old woman who developed corneal pain after LASIK and subsequent PRK enhancement, reporting an Ocular Surface Disease Index score of 100. Using patch-clamp and Ca
Identifiants
pubmed: 39226353
doi: 10.1073/pnas.2406186121
doi:
Substances chimiques
Capsaicin
S07O44R1ZM
TRPV Cation Channels
0
Bradykinin
S8TIM42R2W
TRPV1 protein, human
0
Types de publication
Journal Article
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2406186121Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.