Prognostic risk factors for pyogenic liver abscess caused by Klebsiella pneumoniae.
Humans
Liver Abscess, Pyogenic
/ microbiology
Klebsiella pneumoniae
/ isolation & purification
Male
Risk Factors
Female
Klebsiella Infections
/ complications
Middle Aged
Shock, Septic
/ microbiology
Prognosis
Aged
Intensive Care Units
/ statistics & numerical data
Cholesterol
/ blood
Procalcitonin
/ blood
Blood Glucose
/ metabolism
Retrospective Studies
Logistic Models
Severity of Illness Index
Klebsiella pneumoniae
Blood bacteriological culture
Pyogenic liver abscess
Septic shock
Journal
BMC gastroenterology
ISSN: 1471-230X
Titre abrégé: BMC Gastroenterol
Pays: England
ID NLM: 100968547
Informations de publication
Date de publication:
03 Sep 2024
03 Sep 2024
Historique:
received:
09
01
2024
accepted:
29
08
2024
medline:
4
9
2024
pubmed:
4
9
2024
entrez:
3
9
2024
Statut:
epublish
Résumé
Pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae can vary in severity, and several risk factors for the development of organ dysfunction in PLA have been implicated. However, few studies to date have explored the most common risk factors for clinical severity. We conducted a study on patients with PLA caused by Klebsiella pneumoniae between February 2013 and December 2022.Using logistic regression analysis, we sought to identify factors associated with positive blood culture, septic shock, and intensive care unit (ICU) admission. After included 200 patients, we found that an elevated procalcitonin (PCT) level (p = 0.03), higher glucose level (p = 0.03), and lower total cholesterol (TC) level (p = 0.01) were associated with a higher likelihood of positive blood bacteriological culture. Additionally, an increased PCT level (p = 0.02) and lower TC level (p < 0.01) were associated with an elevated risk of septic shock. Furthermore, a higher PCT level (p < 0.01) was associated with a higher probability of ICU admission. In patients with PLA caused by Klebsiella pneumoniae, the PCT, glucose, and TC levels were found to be associated with positive blood culture, septic shock, and ICU admission.
Sections du résumé
BACKGROUND
BACKGROUND
Pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae can vary in severity, and several risk factors for the development of organ dysfunction in PLA have been implicated. However, few studies to date have explored the most common risk factors for clinical severity.
METHODS
METHODS
We conducted a study on patients with PLA caused by Klebsiella pneumoniae between February 2013 and December 2022.Using logistic regression analysis, we sought to identify factors associated with positive blood culture, septic shock, and intensive care unit (ICU) admission.
RESULTS
RESULTS
After included 200 patients, we found that an elevated procalcitonin (PCT) level (p = 0.03), higher glucose level (p = 0.03), and lower total cholesterol (TC) level (p = 0.01) were associated with a higher likelihood of positive blood bacteriological culture. Additionally, an increased PCT level (p = 0.02) and lower TC level (p < 0.01) were associated with an elevated risk of septic shock. Furthermore, a higher PCT level (p < 0.01) was associated with a higher probability of ICU admission.
CONCLUSION
CONCLUSIONS
In patients with PLA caused by Klebsiella pneumoniae, the PCT, glucose, and TC levels were found to be associated with positive blood culture, septic shock, and ICU admission.
Identifiants
pubmed: 39227812
doi: 10.1186/s12876-024-03391-9
pii: 10.1186/s12876-024-03391-9
doi:
Substances chimiques
Cholesterol
97C5T2UQ7J
Procalcitonin
0
Blood Glucose
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
298Informations de copyright
© 2024. The Author(s).
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