Simulated weightlessness procedure, head-down bed rest has reversible effects on the metabolism of rhesus macaque.
Metabolomics
Rhesus macaque
Simulated weightlessness
Journal
Molecular brain
ISSN: 1756-6606
Titre abrégé: Mol Brain
Pays: England
ID NLM: 101468876
Informations de publication
Date de publication:
03 Sep 2024
03 Sep 2024
Historique:
received:
10
05
2024
accepted:
07
08
2024
medline:
4
9
2024
pubmed:
4
9
2024
entrez:
3
9
2024
Statut:
epublish
Résumé
It is a consensus in the international manned space field that factors such as microgravity during the space flight can cause anxiety, depression and other important brain function abnormalities in astronauts. However, the neural mechanism at the molecular level is still unclear. Due to the limitations of research conditions, studies of biological changes in the primate brain have been comparatively few. We took advantage of -6° head-down bed rest (HDBR), one of the most implemented space analogues on the ground, to investigate the effects of simulated weightlessness on non-human primate brain metabolites. The Rhesus Macaque monkeys in the experiment were divided into three groups: the control group, the 42-day simulated weightlessness group with HDBR, and the recovery group, which had 28 days of free activity in the home cage after the HDBR. Liquid chromatography-mass spectrometry (LC-MS) was used to perform metabolomics analysis on specific brain areas of the monkeys under three experimental conditions. Our results show that simulated weightlessness can cause neurotransmitter imbalances, the amino acid and energy metabolism disorders, and hormone disturbances. But these metabolomics changes are reversible after recovery. Our study suggests that long-term brain damage in space flight might be reversible at the metabolic level. This lays a technical foundation for ensuring brain health and enhancing the brain function in future space studies.
Identifiants
pubmed: 39227961
doi: 10.1186/s13041-024-01133-2
pii: 10.1186/s13041-024-01133-2
doi:
Substances chimiques
Neurotransmitter Agents
0
Amino Acids
0
Hormones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
65Subventions
Organisme : National Key Research and Development Program of China
ID : 2018YFE0126700
Organisme : Shanghai Education Commission Research and Innovation Program
ID : 2019-01-07-00-02-E00037
Organisme : Shanghai Municipal Commission of Science and Technology Program
ID : 21dz2210100
Organisme : Shanghai Municipal Commission of Science and Technology Program
ID : 2021SHZDZX
Organisme : the "111" Program of Higher Education Discipline Innovation
ID : none
Organisme : China Postdoctoral Science Foundation
ID : 2021M702137
Organisme : Natural Science Foundation of Chongqing
ID : cstc2021jcyj-msxmX1176
Organisme : Natural Science Foundation of Chongqing
ID : 2022NSCQ-MSX1304
Informations de copyright
© 2024. The Author(s).
Références
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