Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
04 Sep 2024
Historique:
received: 11 03 2023
accepted: 27 08 2024
medline: 5 9 2024
pubmed: 5 9 2024
entrez: 4 9 2024
Statut: aheadofprint

Résumé

Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk

Identifiants

DOI: 10.1038/s41586-024-07993-x PMID: 39231480
pubmed: 39231480
doi: 10.1038/s41586-024-07993-x
pii: 10.1038/s41586-024-07993-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

Auteurs

Minoru Takaoka (M)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
ORCID: 0000-0002-8515-8282

Xiaohui Zhao (X)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
ORCID: 0000-0001-9922-2815

Hwee Ying Lim (HY)

Immunology Translational Research Programme, Yong Loo Lin School of Medicine, Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.

Costan G Magnussen (CG)

Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
ORCID: 0000-0002-6238-5730

Owen Ang (O)

Immunology Translational Research Programme, Yong Loo Lin School of Medicine, Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.
ORCID: 0000-0002-7210-1586

Nadine Suffee (N)

Université de Paris, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.
ORCID: 0000-0001-9277-5089

Patricia R Schrank (PR)

Department of Integrative Biology & Physiology, Center for Immunology, University of Minnesota, Minneapolis, USA.

Wei Siong Ong (WS)

Immunology Translational Research Programme, Yong Loo Lin School of Medicine, Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.

Dimitrios Tsiantoulas (D)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0002-7743-3192

Felix Sommer (F)

Institute of Clinical Molecular Biology, University of Kiel and University Hospital Schleswig Holstein (UKSH), Kiel, Germany.
ORCID: 0000-0002-6545-3487

Sarajo K Mohanta (SK)

Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
ORCID: 0000-0001-6144-4092

James Harrison (J)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
ORCID: 0000-0003-4960-5062

Yaxing Meng (Y)

Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

Ludivine Laurans (L)

Université de Paris, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.

Feitong Wu (F)

Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.

Yuning Lu (Y)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.

Leanne Masters (L)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.

Stephen A Newland (SA)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.

Laura Denti (L)

Institute of Ophthalmology, University College London, London, UK.
ORCID: 0000-0002-6000-5765

Mingyang Hong (M)

Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.

Mouna Chajadine (M)

Université de Paris, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.

Markus Juonala (M)

Department of Medicine, University of Turku, Turku, Finland.
Division of Medicine, Turku University Hospital, Turku, Finland.
ORCID: 0000-0001-9498-364X

Juhani S Koskinen (JS)

Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Division of Medicine, Turku University Hospital, Turku, Finland.
Department of Medicine, Satakunta Central Hospital, Pori, Finland.
ORCID: 0000-0002-5920-9728

Mika Kähönen (M)

Department of Clinical Physiology, University of Tampere, Tampere, Finland.
Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland.
Finnish Cardiovascular Research Center Tampere, University of Tampere, Tampere, Finland.

Katja Pahkala (K)

Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

Suvi P Rovio (SP)

Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

Juha Mykkänen (J)

Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
ORCID: 0000-0001-9898-2660

Russell Thomson (R)

Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Analytical Edge, Hobart, Tasmania, Australia.

Tsuneyasu Kaisho (T)

Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan.
ORCID: 0000-0003-2616-1665

Andreas J R Habenicht (AJR)

Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
ORCID: 0000-0003-2901-3027

Marc Clement (M)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
ORCID: 0000-0002-6479-8360

Alain Tedgui (A)

Université de Paris, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.
ORCID: 0000-0002-7229-4875

Hafid Ait-Oufella (H)

Université de Paris, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.
ORCID: 0000-0002-2955-0183

Tian X Zhao (TX)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
ORCID: 0000-0003-0202-5255

Meritxell Nus (M)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK.
ORCID: 0000-0002-6378-8910

Christiana Ruhrberg (C)

Institute of Ophthalmology, University College London, London, UK.
ORCID: 0000-0002-3212-9381

Soraya Taleb (S)

Université de Paris, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France.
ORCID: 0000-0002-6650-619X

Jesse W Williams (JW)

Department of Integrative Biology & Physiology, Center for Immunology, University of Minnesota, Minneapolis, USA.
ORCID: 0000-0003-3815-0891

Olli T Raitakari (OT)

Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.

Véronique Angeli (V)

Immunology Translational Research Programme, Yong Loo Lin School of Medicine, Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.
ORCID: 0000-0002-2759-3497

Ziad Mallat (Z)

Department of Medicine, Cardiovascular Division, University of Cambridge, Heart and Lung Research Institute, Cambridge, UK. zm255@medschl.cam.ac.uk.
Université de Paris, Institut National de la Santé et de la Recherche Médicale, U970, PARCC, Paris, France. zm255@medschl.cam.ac.uk.
ORCID: 0000-0003-0443-7878

Classifications MeSH