Transient colonizing microbes promote gut dysbiosis and functional impairment.

Dysbiosis / microbiology Gastrointestinal Microbiome Humans Metagenomics / methods Sweden Bacteria / classification Feces / microbiology Longitudinal Studies Metagenome Adult Bioreactors / microbiology Fermentation

Journal

NPJ biofilms and microbiomes

ISSN: 2055-5008

Titre abrégé: NPJ Biofilms Microbiomes

Pays: United States

ID NLM: 101666944

Informations de publication

Date de publication:
08 Sep 2024

Historique:

received: 20 11 2023

accepted: 27 08 2024

medline: 9 9 2024

pubmed: 9 9 2024

entrez: 8 9 2024

Statut: epublish

Résumé

Species composition of the healthy adult gut microbiota tends to be stable over time. Destabilization of the gut microbiome under the influence of different factors is the main driver of the microbial dysbiosis and subsequent impacts on host physiology. Here, we used metagenomics data from a Swedish longitudinal cohort, to determine the stability of the gut microbiome and uncovered two distinct microbial species groups; persistent colonizing species (PCS) and transient colonizing species (TCS). We validated the continuation of this grouping, generating gut metagenomics data for additional time points from the same Swedish cohort. We evaluated the existence of PCS/TCS across different geographical regions and observed they are globally conserved features. To characterize PCS/TCS phenotypes, we performed bioreactor fermentation with faecal samples and metabolic modeling. Finally, using chronic disease gut metagenome and other multi-omics data, we identified roles of TCS in microbial dysbiosis and link with abnormal changes to host physiology.

Identifiants

DOI: 10.1038/s41522-024-00561-1 PMID: 39245657

pubmed: 39245657

doi: 10.1038/s41522-024-00561-1

pii: 10.1038/s41522-024-00561-1

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

Subventions

Organisme : RCUK | Engineering and Physical Sciences Research Council (EPSRC)

ID : EP/S001301/1

Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)

ID : BB/S016899/1

Organisme : Science for Life Laboratory (SciLifeLab)

ID : N/A

Informations de copyright

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