The Discover In-Hospital Cardiac Arrest (Discover IHCA) Study: An Investigation of Hospital Practices After In-Hospital Cardiac Arrest.
Journal
Critical care explorations
ISSN: 2639-8028
Titre abrégé: Crit Care Explor
Pays: United States
ID NLM: 101746347
Informations de publication
Date de publication:
01 Sep 2024
01 Sep 2024
Historique:
medline:
11
9
2024
pubmed:
11
9
2024
entrez:
11
9
2024
Statut:
epublish
Résumé
In-hospital cardiac arrest (IHCA) is a significant public health burden. Rates of return of spontaneous circulation (ROSC) have been improving, but the best way to care for patients after the initial resuscitation remains poorly understood, and improvements in survival to discharge are stagnant. Existing North American cardiac arrest databases lack comprehensive data on the post-resuscitation period, and we do not know current post-IHCA practice patterns. To address this gap, we developed the Discover In-Hospital Cardiac Arrest (Discover IHCA) study, which will thoroughly evaluate current post-IHCA care practices across a diverse cohort. Our study collects granular data on post-IHCA treatment practices, focusing on temperature control and prognostication, with the objective of describing variation in current post-IHCA practice. This is a multicenter, prospectively collected, observational cohort study of patients who have suffered IHCA and have been successfully resuscitated (achieved ROSC). There are 24 enrolling hospital systems (23 in the United States) with 69 individual enrolling hospitals (39 in the United States). We developed a standardized data dictionary, and data collection began in October 2023, with a projected 1000 total enrollments. Discover IHCA is endorsed by the Society of Critical Care Medicine. The study collects data on patient characteristics including pre-arrest frailty, arrest characteristics, and detailed information on post-arrest practices and outcomes. Data collection on post-IHCA practice was structured around current American Heart Association and European Resuscitation Council guidelines. Among other data elements, the study captures post-arrest temperature control interventions and post-arrest prognostication methods. Analysis will evaluate variations in practice and their association with mortality and neurologic function. We expect this study, Discover IHCA, to identify variability in practice and outcomes following IHCA, and be a vital resource for future investigations into best-practice for managing patients after IHCA.
Identifiants
pubmed: 39258957
doi: 10.1097/CCE.0000000000001149
pii: 02107256-202409000-00010
doi:
Types de publication
Journal Article
Observational Study
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1149Informations de copyright
Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.
Déclaration de conflit d'intérêts
The authors have disclosed that they do not have any potential conflicts of interest.
Références
Andersen LW, Holmberg MJ, Berg KM, et al.: In-hospital cardiac arrest: A review. JAMA 2019; 321:1200–1210
Holmberg MJ, Ross CE, Fitzmaurice GM, et al.; American Heart Association’s Get With The Guidelines–Resuscitation Investigators: Annual incidence of adult and pediatric in-hospital cardiac arrest in the United States. Circ Cardiovasc Qual Outcomes 2019; 12:e005580
Girotra S, Nallamothu BK, Spertus JA, et al.; American Heart Association Get with the Guidelines–Resuscitation Investigators: Trends in survival after in-hospital cardiac arrest. N Engl J Med 2012; 367:1912–1920
Wiberg S, Holmberg MJ, Donnino MW, et al.; American Heart Association’s Get With The Guidelines®-Resuscitation Investigators: Age-dependent trends in survival after adult in-hospital cardiac arrest. Resuscitation 2020; 151:189–196
Sandroni C, Nolan J, Cavallaro F, et al.: In-hospital cardiac arrest: Incidence, prognosis and possible measures to improve survival. Intensive Care Med 2007; 33:237–245
Benjamin EJ, Virani SS, Callaway CW, et al.; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee: Heart Disease and Stroke Statistics-2018 update: A report from the American Heart Association. Circulation 2018; 137:e67–e492
Kleinman ME, Perkins GD, Bhanji F, et al.: ILCOR scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care: A consensus statement. Resuscitation 2018; 127:132–146
Wyckoff MH, Greif R, Morley PT, et al.; Collaborators: 2022 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations: Summary from the basic life support; advanced life support; pediatric life support; neonatal life support; education, implementation, and teams; and first aid task forces. Resuscitation 2022; 181:208–288
Zeiner A, Holzer M, Sterz F, et al.: Hyperthermia after cardiac arrest is associated with an unfavorable neurologic outcome. Arch Intern Med 2001; 161:2007–2012
Paratz ED, Rowsell L, Zentner D, et al.; Australian UCDP Registry: Cardiac arrest and sudden cardiac death registries: A systematic review of global coverage. Open Heart 2020; 7:e001195
Moskowitz A, Holmberg MJ, Donnino MW, et al.: In-hospital cardiac arrest: Are we overlooking a key distinction? Curr Opin Crit Care 2018; 24:151–157
Qadir N, Bartz RR, Cooter ML, et al.; Severe ARDS: Generating Evidence (SAGE) Study Investigators: Variation in early management practices in moderate-to-severe ARDS in the United States: The severe ARDS: Generating evidence study. Chest 2021; 160:1304–1315
Chen JT, Roberts R, Fazzari MJ, et al.; VOLUME-CHASERS Study Group and Society of Critical Care Medicine Discovery Network: Variation in fluid and vasopressor use in shock with and without physiologic assessment: A multicenter observational study. Crit Care Med 2020; 48:1436–1444
Perman SM, Elmer J, Maciel CB, et al.; American Heart Association: 2023 American Heart Association focused update on adult advanced cardiovascular life support: An update to the American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2024; 149:e254–e273
Panchal AR, Bartos JA, Cabañas JG, et al.; Adult Basic and Advanced Life Support Writing Group: Part 3: Adult basic and advanced life support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2020; 142:S366–S468
Nolan JP, Sandroni C, Böttiger BW, et al.: European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: Post-resuscitation care. Intensive Care Med 2021; 47:369–421
Society of Critical Care Medicine: Discovery, the Critical Care Research Network. 2021. Available at: https://www.sccm.org/Research/Discovery-Research-Network. Accessed December 20, 2023
Walkey AJ, Kumar VK, Harhay MO, et al.: The Viral Infection and Respiratory Illness Universal Study (VIRUS): An international registry of coronavirus 2019-related critical illness. Crit Care Explor 2020; 2:e0113
Society of Critical Care Medicine: Publications. 2021. Available at: https://www.sccm.org/Research/Discovery-Research-Network/Discovery-Activities/Publications. Accessed December 20, 2023
Society of Critical Care Medicine: Discover IHCA Project. 2023. Available at: https://sccm.org/Research/Discovery-Research-Network/Discovery-Activities/Discover-IHCA-Project. Accessed December 20, 2023
U.S. Department of Health and Human Services: Health Information Privacy. 2015. 45 CFR 164.501, 164.508, 164.512(i). Available at: https://www.hhs.gov/hipaa/for-professionals/special-topics/research/index.html. Accessed December 28, 2023
Church S, Rogers E, Rockwood K, et al.: A scoping review of the Clinical Frailty Scale. BMC Geriatr 2020; 20:393
Jacobs I, Nadkarni V, Bahr J, et al.; International Liaison Committee on Resuscitation: Cardiac arrest and cardiopulmonary resuscitation outcome reports: Update and simplification of the Utstein templates for resuscitation registries: A statement for healthcare professionals from a task force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian Resuscitation Council, New Zealand Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Councils of Southern Africa). Circulation 2004; 110:3385–3397
Cummins RO, Chamberlain D, Hazinski MF, et al.: Recommended guidelines for reviewing, reporting, and conducting research on in-hospital resuscitation: The in-hospital “Utstein style.” American Heart Association. Ann Emerg Med 1997; 29:650–679
Nielsen N, Wetterslev J, Cronberg T, et al.; TTM Trial Investigators: Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 2013; 369:2197–2206
Lascarrou JB, Merdji H, Le Gouge A, et al.; CRICS-TRIGGERSEP Group: Targeted temperature management for cardiac arrest with nonshockable rhythm. N Engl J Med 2019; 381:2327–2337
Jennett B, Bond M: Assessment of outcome after severe brain damage. Lancet 1975; 1:480–484