Swarms of Enzymatic Nanobots for Efficient Gene Delivery.

Humans Animals Mice Polylactic Acid-Polyglycolic Acid Copolymer / chemistry Cell Line, Tumor Nanoparticles / chemistry DNA / chemistry Transfection / methods Urease / metabolism Plasmids / metabolism Gene Transfer Techniques Polyglycolic Acid / chemistry Lactic Acid / chemistry Urinary Bladder Neoplasms / metabolism
drug delivery enzyme catalysis gene delivery nanobots pDNA swarming transfection

Journal

ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991

Informations de publication

Date de publication:
11 Sep 2024
Historique:
medline: 12 9 2024
pubmed: 12 9 2024
entrez: 12 9 2024
Statut: ppublish

Résumé

This study investigates the synthesis and optimization of nanobots (NBs) loaded with pDNA using the layer-by-layer (LBL) method and explores the impact of their collective motion on the transfection efficiency. NBs consist of biocompatible and biodegradable poly(lactic-

Identifiants

DOI: 10.1021/acsami.4c08770 PMID: 39262054
pubmed: 39262054
doi: 10.1021/acsami.4c08770
doi:

Substances chimiques

Polylactic Acid-Polyglycolic Acid Copolymer 1SIA8062RS
DNA 9007-49-2
Urease EC 3.5.1.5
Polyglycolic Acid 26009-03-0
Lactic Acid 33X04XA5AT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

47192-47205

Auteurs

Juan C Fraire (JC)

Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10-12, 08028 Barcelona, Spain.
ORCID: 0000-0002-4887-2161

Carles Prado-Morales (C)

Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10-12, 08028 Barcelona, Spain.
Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, 08028 Barcelona, Spain.

Ana Aldaz Sagredo (A)

Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10-12, 08028 Barcelona, Spain.

Ainhoa G Caelles (AG)

Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10-12, 08028 Barcelona, Spain.

Florencia Lezcano (F)

Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10-12, 08028 Barcelona, Spain.

Xander Peetroons (X)

Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10-12, 08028 Barcelona, Spain.

Anna C Bakenecker (AC)

Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10-12, 08028 Barcelona, Spain.

Valerio Di Carlo (V)

Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10-12, 08028 Barcelona, Spain.

Samuel Sánchez (S)

Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 10-12, 08028 Barcelona, Spain.
Catalan Institute for Research and Advanced Studies (ICREA), Passeig de Lluís Companys 23, 08010 Barcelona, Spain.
ORCID: 0000-0001-9713-9997

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Eucaryotes › Animaux › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Acide polyglycolique › Copolymère d'acide poly(lactique-co-glycolique) › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Transfection › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Urease › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Plasmides › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques de transfert de gènes › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Acide polyglycolique › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › Swarms of Enzymatic Nanobots for Efficient...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs de la vessie urinaire › Swarms of Enzymatic Nanobots for Efficient...