Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation.
Atrial Fibrillation
/ immunology
Humans
Pericardium
/ metabolism
Adipose Tissue
/ metabolism
Memory T Cells
/ immunology
Male
CD8-Positive T-Lymphocytes
/ immunology
Transcriptome
Myocytes, Cardiac
/ metabolism
Female
Middle Aged
Gene Expression Profiling
Aged
Phenotype
Calcium Signaling
Apoptosis
Immunologic Memory
Transcription, Genetic
Case-Control Studies
Heart Atria
/ pathology
Fibrosis
/ pathology
Epicardial Adipose Tissue
Journal
Nature cardiovascular research
ISSN: 2731-0590
Titre abrégé: Nat Cardiovasc Res
Pays: England
ID NLM: 9918284280206676
Informations de publication
Date de publication:
Sep 2024
Sep 2024
Historique:
received:
20
09
2023
accepted:
29
07
2024
medline:
14
9
2024
pubmed:
14
9
2024
entrez:
13
9
2024
Statut:
ppublish
Résumé
Atrial fibrillation (AF) is the most common sustained arrhythmia and carries an increased risk of stroke and heart failure. Here we investigated how the immune infiltrate of human epicardial adipose tissue (EAT), which directly overlies the myocardium, contributes to AF. Flow cytometry analysis revealed an enrichment of tissue-resident memory T (T
Identifiants
pubmed: 39271815
doi: 10.1038/s44161-024-00532-x
pii: 10.1038/s44161-024-00532-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1067-1082Subventions
Organisme : British Heart Foundation (BHF)
ID : PG/16/79/32419
Organisme : British Heart Foundation (BHF)
ID : FS/13/49/30421
Organisme : British Heart Foundation (BHF)
ID : AA/18/5/34222
Organisme : British Heart Foundation (BHF)
ID : FS/4yPhD/F/22/34174B
Organisme : RCUK | MRC | Medical Research Foundation
ID : MR/T008059/1
Organisme : RCUK | MRC | Medical Research Foundation
ID : MR/T008059/1
Organisme : RCUK | MRC | Medical Research Foundation
ID : MR/T008059/1
Informations de copyright
© 2024. The Author(s).
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