Identification of a Clade-Specific HLA-C*03:02 CTL Epitope GY9 Derived from the HIV-1 p17 Matrix Protein.

gag Gene Products, Human Immunodeficiency Virus / immunology Humans Epitopes, T-Lymphocyte / immunology HLA-C Antigens / immunology HIV-1 / immunology T-Lymphocytes, Cytotoxic / immunology Amino Acid Sequence Protein Binding HIV Infections / immunology HIV Antigens
HIV control HLA-C*03:02 immunoinformatics

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
06 Sep 2024
Historique:
received: 07 10 2023
revised: 20 11 2023
accepted: 24 11 2023
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

Efforts towards an effective HIV-1 vaccine have remained mainly unsuccessful. There is increasing evidence for a potential role of HLA-C-restricted CD8

Identifiants

DOI: 10.3390/ijms25179683 PMID: 39273630
pubmed: 39273630
pii: ijms25179683
doi: 10.3390/ijms25179683
pii:
doi:

Substances chimiques

gag Gene Products, Human Immunodeficiency Virus 0
Epitopes, T-Lymphocyte 0
HLA-C Antigens 0
p17 protein, Human Immunodeficiency Virus Type 1 0
HIV Antigens 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Makerere University
ID : MakRIF_PhD_Supoort

Auteurs

Samuel Kyobe (S)

Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.
ORCID: 0000-0003-0444-5608

Savannah Mwesigwa (S)

Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.
Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.

Gyaviira Nkurunungi (G)

The Medical Research Council/Uganda Virus Research Institute & London School Hygine Tropical Medicine Uganda Research Unit, Entebbe P.O. Box 49, Uganda.
Department of Infection Biology, London School of Hygiene & Tropical Medicine, Keppel Street London, London WC1E 7HT, UK.
ORCID: 0000-0003-4062-9105

Gaone Retshabile (G)

Department of Biological Sciences, University of Botswana, Gaborone Private Bag UB 0022, Botswana.
ORCID: 0000-0003-1721-0963

Moses Egesa (M)

The Medical Research Council/Uganda Virus Research Institute & London School Hygine Tropical Medicine Uganda Research Unit, Entebbe P.O. Box 49, Uganda.
Department of Infection Biology, London School of Hygiene & Tropical Medicine, Keppel Street London, London WC1E 7HT, UK.
ORCID: 0000-0001-5136-868X

Eric Katagirya (E)

Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.
ORCID: 0000-0002-9662-2861

Marion Amujal (M)

Department of Immunology and Molecular Biology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.
ORCID: 0000-0001-7406-3926

Busisiwe C Mlotshwa (BC)

Department of Biological Sciences, University of Botswana, Gaborone Private Bag UB 0022, Botswana.

Lesedi Williams (L)

Department of Biological Sciences, University of Botswana, Gaborone Private Bag UB 0022, Botswana.

Hakim Sendagire (H)

Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala P.O. Box 7072, Uganda.

Dithan Kiragga (D)

Baylor College of Medicine Children's Foundation, Kampala P.O. Box 72052, Uganda.

Graeme Mardon (G)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.

Mogomotsi Matshaba (M)

Pediatric Retrovirology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Botswana-Baylor Children's Clinical Centre of Excellence, Gaborone Private Bag BR 129, Botswana.

Neil A Hanchard (NA)

National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA.

Jacqueline Kyosiimire-Lugemwa (J)

The Medical Research Council/Uganda Virus Research Institute & London School Hygine Tropical Medicine Uganda Research Unit, Entebbe P.O. Box 49, Uganda.
ORCID: 0000-0001-7868-9504

David Robinson (D)

Department of Chemistry and Forensics, School of Science and Technology, Nottingham Trent University Clifton Lane, Nottingham NG11 8NS, UK.
ORCID: 0000-0003-2760-7163

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines nucléocapside › Protéines du core viral › Produits du gène gag › Produits du gène gag du virus de l'immunodéficience humaine › Identification of a Clade-Specific HLA-C*03:02...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of a Clade-Specific HLA-C*03:02...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Déterminants antigéniques des lymphocytes T › Identification of a Clade-Specific HLA-C*03:02...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-C › Identification of a Clade-Specific HLA-C*03:02...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Identification of a Clade-Specific HLA-C*03:02...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T cytotoxiques › Identification of a Clade-Specific HLA-C*03:02...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Identification of a Clade-Specific HLA-C*03:02...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Identification of a Clade-Specific HLA-C*03:02...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Identification of a Clade-Specific HLA-C*03:02...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › Antigènes du VIH › Identification of a Clade-Specific HLA-C*03:02...