Efficacy of Food Supplement Based on Monacolins, γ-Oryzanol, and γ-Aminobutyric Acid in Mild Dyslipidemia: A Randomized, Double-Blind, Parallel-Armed, Placebo-Controlled Clinical Trial.

Humans Double-Blind Method Male Dietary Supplements Female Middle Aged Dyslipidemias / drug therapy Phenylpropionates / therapeutic use Adult gamma-Aminobutyric Acid Lovastatin / therapeutic use Cholesterol, LDL / blood Treatment Outcome Cholesterol, HDL / blood
mild dyslipidemia monacolin K randomized clinical trial red yeast rice γ-aminobutyric acid γ-oryzanol

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
04 Sep 2024
Historique:
received: 31 07 2024
revised: 24 08 2024
accepted: 31 08 2024
medline: 14 9 2024
pubmed: 14 9 2024
entrez: 14 9 2024
Statut: epublish

Résumé

The risk of cardiovascular disease (CVD) is approximately doubled in subjects with hypercholesterolemia compared to those with normal blood cholesterol levels. Monacolin K (MK), the main active substance in rice fermented by the

Identifiants

DOI: 10.3390/nu16172983 PMID: 39275298
pubmed: 39275298
pii: nu16172983
doi: 10.3390/nu16172983
pii:
doi:

Substances chimiques

gamma-oryzanol SST9XCL51M
Phenylpropionates 0
gamma-Aminobutyric Acid 56-12-2
Lovastatin 9LHU78OQFD
Cholesterol, LDL 0
Cholesterol, HDL 0

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Lorenza Francesca De Lellis (LF)

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.

Maria Vittoria Morone (MV)

Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania "L. Vanvitelli", 80138 Naples, Italy.
ORCID: 0009-0000-0810-8460

Daniele Giuseppe Buccato (DG)

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.

Marcello Cordara (M)

School of Medicine, University of Milano-Bicocca, 20126 Milan, Italy.

Danaè S Larsen (DS)

School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand.

Hammad Ullah (H)

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
ORCID: 0000-0001-9437-676X

Roberto Piccinocchi (R)

Level 1 Medical Director Anaesthesia and Resuscitation A. U. O. Luigi Vanvitelli, Via Santa Maria di Costantinopoli, 80138 Naples, Italy.

Gaetano Piccinocchi (G)

Comegen S.c.S., Società Cooperativa Sociale di Medici di Medicina Generale, Viale Maria Bakunin 41, 80125 Naples, Italy.
ORCID: 0000-0002-3095-2198

Paulraj Balaji (P)

PG and Research Centre in Biotechnology, MGR College, Hosur 635130, TN, India.
ORCID: 0000-0002-6839-4785

Alessandra Baldi (A)

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
ORCID: 0000-0002-2877-9445

Alessandro Di Minno (A)

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
CEINGE-Biotecnologie Avanzate, Via Gaetano Salvatore 486, 80145 Naples, Italy.
ORCID: 0000-0001-8084-9976

Hesham R El-Seedi (HR)

Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia.
ORCID: 0000-0002-2519-6690

Roberto Sacchi (R)

Applied Statistic Unit, Department of Earth and Environmental Sciences, University of Pavia, Viale Taramelli 24, 27100 Pavia, Italy.
ORCID: 0000-0002-6199-0074

Maria Daglia (M)

Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.
ORCID: 0000-0002-4870-7713

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méthode en double aveugle › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Phénylpropionates › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Lovastatine › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines LDL › Cholestérol LDL › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Efficacy of Food Supplement Based on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines HDL › Cholestérol HDL › Efficacy of Food Supplement Based on...