Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
16 Sep 2024
Historique:
medline: 17 9 2024
pubmed: 17 9 2024
entrez: 16 9 2024
Statut: aheadofprint

Résumé

This study introduces a novel multitargeting strategy that combines carbonic anhydrase (CA) activators and cholinesterase (ChE) inhibitors to enhance cognitive functions. A series of tacrine-based derivatives with amine/amino acid moieties were synthesized and evaluated for their dual activity on brain CA isoforms and ChEs (AChE and BChE). Several derivatives, notably compounds

Identifiants

DOI: 10.1021/acs.jmedchem.4c01866 PMID: 39283654
pubmed: 39283654
doi: 10.1021/acs.jmedchem.4c01866
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Alessio Nocentini (A)

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Florence 50019, Italy.
ORCID: 0000-0003-3342-702X

Alessia Costa (A)

Department of NEUROFARBA, Section of Pharmacology and Toxicology, Laboratory of Ocular and Neuropsychopharmacology (Braeye Lab), University of Florence, Viale Pieraccini 6, Florence 50139, Italy.

Alessandro Bonardi (A)

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, Sesto Fiorentino, Florence 50019, Italy.

Andrea Ammara (A)

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Florence 50019, Italy.
ORCID: 0000-0001-7364-1499

Simone Giovannuzzi (S)

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Florence 50019, Italy.

Andrea Petreni (A)

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Florence 50019, Italy.

Gianluca Bartolucci (G)

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Florence 50019, Italy.
ORCID: 0000-0002-5631-8769

Barbara Rani (B)

Department of NEUROFARBA, Section of Pharmacology and Toxicology, Laboratory of Ocular and Neuropsychopharmacology (Braeye Lab), University of Florence, Viale Pieraccini 6, Florence 50139, Italy.

Manuela Leri (M)

Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence 50134, Italy.

Monica Bucciantini (M)

Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence 50134, Italy.

José G Fernández-Bolaños (JG)

Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Seville 41012, Spain.
ORCID: 0000-0003-1499-0650

Óscar López (Ó)

Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Seville 41012, Spain.
ORCID: 0000-0003-2896-6993

Maria Beatrice Passani (MB)

Department of Health Sciences, Laboratory of Ocular and Neuropsychopharmacology (Braeye Lab), University of Florence, Viale Pieraccini 6, Florence 50139, Italy.

Gustavo Provensi (G)

Department of NEUROFARBA, Section of Pharmacology and Toxicology, Laboratory of Ocular and Neuropsychopharmacology (Braeye Lab), University of Florence, Viale Pieraccini 6, Florence 50139, Italy.

Paola Gratteri (P)

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Florence, Via U. Schiff 6, Sesto Fiorentino, Florence 50019, Italy.
ORCID: 0000-0002-9137-2509

Claudiu T Supuran (CT)

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Florence 50019, Italy.
ORCID: 0000-0003-4262-0323

Classifications MeSH