Low-density lipoprotein cholesterol and the risk of hyperemesis gravidarum: a Mendelian randomization study.

Humans Female Mendelian Randomization Analysis Pregnancy Cholesterol, LDL / blood Hyperemesis Gravidarum / genetics Polymorphism, Single Nucleotide Genome-Wide Association Study Genetic Predisposition to Disease Risk Factors
Lipid metabolism hyperemesis gravidarum low-density lipoprotein cholesterol mendelian randomization single nucleotide polymorphisms

Journal

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
ISSN: 1476-4954
Titre abrégé: J Matern Fetal Neonatal Med
Pays: England
ID NLM: 101136916

Informations de publication

Date de publication:
Dec 2024
Historique:
medline: 17 9 2024
pubmed: 17 9 2024
entrez: 16 9 2024
Statut: ppublish

Résumé

The inconsistency in conclusions from early observational studies has sparked our interest in elucidating the relationship between lipid levels and susceptibility to hyperemesis gravidarum (HG). This study wishes to employed Mendelian randomization analysis to investigate the causal relationship between low-density lipoprotein cholesterol (LDL-C) and HG. We employed Tow-Sample MR analysis to investigate the causal associations between LDL-C and HG. Specific variables were selected from GWAS database for MR analysis, using single nucleotide polymorphisms (SNPs) as our instruments. The threshold for significant SNPs as genetic instruments has been set at 5 × 10 Our MR results identified the effect of genetically predicted increased LDL-C levels on increased genetic susceptibility to HG ( This study may have provided evidence of genetically predicted increased LDL-C levels on increased genetic susceptibility to HG. Appropriate lowering LDL-C levels may serve as a preventive and treatment measure for HG.

Identifiants

DOI: 10.1080/14767058.2024.2397722 PMID: 39284761
pubmed: 39284761
doi: 10.1080/14767058.2024.2397722
doi:

Substances chimiques

Cholesterol, LDL 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2397722

Auteurs

Xiaohu Liu (X)

School of Medicine, Kunming University of Science and Technology, Kunming, China.
Department of Medical Genetics, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, The First People's Hospital of Yunnan Province / The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Xiaoting Zhou (X)

School of Medicine, Kunming University of Science and Technology, Kunming, China.
Department of Reproductive Medicine, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, Reproductive Medical Center of Yunnan Province, The First People's Hospital of Yunnan Province / The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Jiao Wang (J)

School of Medicine, Kunming University of Science and Technology, Kunming, China.
Department of Medical Genetics, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, The First People's Hospital of Yunnan Province / The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Aiqi Cai (A)

School of Medicine, Kunming University of Science and Technology, Kunming, China.
Department of Medical Genetics, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, The First People's Hospital of Yunnan Province / The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Yinhong Zhang (Y)

School of Medicine, Kunming University of Science and Technology, Kunming, China.
Department of Medical Genetics, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, The First People's Hospital of Yunnan Province / The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Jinman Zhang (J)

School of Medicine, Kunming University of Science and Technology, Kunming, China.
Department of Medical Genetics, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, The First People's Hospital of Yunnan Province / The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Ze Wu (Z)

School of Medicine, Kunming University of Science and Technology, Kunming, China.
Department of Reproductive Medicine, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, Reproductive Medical Center of Yunnan Province, The First People's Hospital of Yunnan Province / The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.

Baosheng Zhu (B)

School of Medicine, Kunming University of Science and Technology, Kunming, China.
Department of Medical Genetics, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, The First People's Hospital of Yunnan Province / The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
ORCID: 0000-0002-5991-1752

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Low-density lipoprotein cholesterol and the...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Low-density lipoprotein cholesterol and the...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Low-density lipoprotein cholesterol and the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines LDL › Cholestérol LDL › Low-density lipoprotein cholesterol and the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Vomissement › Maladie gravidique précoce › Hyperémèse gravidique › Low-density lipoprotein cholesterol and the...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Low-density lipoprotein cholesterol and the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Low-density lipoprotein cholesterol and the...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Low-density lipoprotein cholesterol and the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Low-density lipoprotein cholesterol and the...