N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
16 Sep 2024
Historique:
received: 09 06 2022
accepted: 02 08 2024
medline: 17 9 2024
pubmed: 17 9 2024
entrez: 16 9 2024
Statut: epublish

Résumé

The ribosome utilizes hydrogen bonding between mRNA codons and aminoacyl-tRNAs to ensure rapid and accurate protein production. Chemical modification of mRNA nucleobases can adjust the strength and pattern of this hydrogen bonding to alter protein synthesis. We investigate how the N1-methylpseudouridine (m

Identifiants

pubmed: 39284850
doi: 10.1038/s41467-024-51301-0
pii: 10.1038/s41467-024-51301-0
doi:

Substances chimiques

Pseudouridine 1445-07-4
RNA, Messenger 0
Codon 0
RNA, Transfer 9014-25-9
1-methylpseudouridine 13860-38-3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8119

Subventions

Organisme : Research Corporation for Science Advancement (Research Corporation)
ID : Cottrell Scholar
Organisme : NIGMS NIH HHS
ID : R35 GM128836
Pays : United States
Organisme : National Science Foundation (NSF)
ID : CAREER 2045562
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R01GM093278

Informations de copyright

© 2024. The Author(s).

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Auteurs

Jeremy Monroe (J)

Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.

Daniel E Eyler (DE)

Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.

Lili Mitchell (L)

RNA and Genome Editing, New England Biolabs Inc., Ipswich, MA, USA.

Indrajit Deb (I)

Department of Biophysics, University of Michigan, Ann Arbor, MI, USA.

Abigail Bojanowski (A)

Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.

Pooja Srinivas (P)

Department of Chemistry, Emory University, Atlanta, GA, USA.

Christine M Dunham (CM)

Department of Chemistry, Emory University, Atlanta, GA, USA.

Bijoyita Roy (B)

RNA and Genome Editing, New England Biolabs Inc., Ipswich, MA, USA.

Aaron T Frank (AT)

Department of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Department of Biophysics, University of Michigan, Ann Arbor, MI, USA.
Computational Chemistry, Arrakis Therapeutics, Waltham, MA, USA.

Kristin S Koutmou (KS)

Department of Chemistry, University of Michigan, Ann Arbor, MI, USA. kkoutmou@umich.edu.

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