N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 Sep 2024
16 Sep 2024
Historique:
received:
09
06
2022
accepted:
02
08
2024
medline:
17
9
2024
pubmed:
17
9
2024
entrez:
16
9
2024
Statut:
epublish
Résumé
The ribosome utilizes hydrogen bonding between mRNA codons and aminoacyl-tRNAs to ensure rapid and accurate protein production. Chemical modification of mRNA nucleobases can adjust the strength and pattern of this hydrogen bonding to alter protein synthesis. We investigate how the N1-methylpseudouridine (m
Identifiants
pubmed: 39284850
doi: 10.1038/s41467-024-51301-0
pii: 10.1038/s41467-024-51301-0
doi:
Substances chimiques
Pseudouridine
1445-07-4
RNA, Messenger
0
Codon
0
RNA, Transfer
9014-25-9
1-methylpseudouridine
13860-38-3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8119Subventions
Organisme : Research Corporation for Science Advancement (Research Corporation)
ID : Cottrell Scholar
Organisme : NIGMS NIH HHS
ID : R35 GM128836
Pays : United States
Organisme : National Science Foundation (NSF)
ID : CAREER 2045562
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R01GM093278
Informations de copyright
© 2024. The Author(s).
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