Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?

CRISPR-Cas Systems / genetics Eukaryota / genetics RNA, Guide, CRISPR-Cas Systems / genetics CRISPR-Associated Proteins / metabolism DNA / genetics Endodeoxyribonucleases / metabolism Humans

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
19 Sep 2024
Historique:
received: 08 08 2024
revised: 12 08 2024
accepted: 12 08 2024
medline: 21 9 2024
pubmed: 21 9 2024
entrez: 20 9 2024
Statut: ppublish

Résumé

Fanzors are recently characterized RNA-guided DNA endonucleases found in eukaryotic organisms. In this issue of Cell, Xu, Saito et al. reveal the structural diversity of Fanzors and identify key features shared with TnpB and Cas12 proteins, providing a comprehensive perspective on their molecular function and evolution.

Identifiants

DOI: 10.1016/j.cell.2024.08.022 PMID: 39303688
pubmed: 39303688
pii: S0092-8674(24)00915-2
doi: 10.1016/j.cell.2024.08.022
pii:
doi:

Substances chimiques

RNA, Guide, CRISPR-Cas Systems 0
CRISPR-Associated Proteins 0
DNA 9007-49-2
Endodeoxyribonucleases EC 3.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5220-5222

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests O.N. is a co-founder, board member, and scientific advisor of Curreio.

Auteurs

Satoshi N Omura (SN)

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Osamu Nureki (O)

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: nureki@bs.s.u-tokyo.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Exploring RNA-guided DNA scissors in...
questionsmedicales.fr › Eucaryotes › Exploring RNA-guided DNA scissors in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Systèmes CRISPR-Cas, ARN, guide › Exploring RNA-guided DNA scissors in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées aux CRISPR › Exploring RNA-guided DNA scissors in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Exploring RNA-guided DNA scissors in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Endonucleases › Endodeoxyribonucleases › Exploring RNA-guided DNA scissors in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Exploring RNA-guided DNA scissors in...