Epidemiology, clinical characteristics, and outcome of infective endocarditis due to Abiotrophia and Granulicatella in a Tertiary Hospital in China, 2015-2023: a retrospective study.
Humans
China
/ epidemiology
Retrospective Studies
Male
Female
Tertiary Care Centers
/ statistics & numerical data
Middle Aged
Aged
Abiotrophia
Carnobacteriaceae
/ isolation & purification
Adult
Endocarditis, Bacterial
/ epidemiology
Gram-Positive Bacterial Infections
/ epidemiology
Endocarditis
/ microbiology
Abiotrophia
Granulicatella
Infective endocarditis
Nutritionally variant streptococci
Viridans group streptococci
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
20 Sep 2024
20 Sep 2024
Historique:
received:
11
05
2024
accepted:
16
09
2024
medline:
21
9
2024
pubmed:
21
9
2024
entrez:
20
9
2024
Statut:
epublish
Résumé
Abiotrophia (ABI) and Granulicatella (GRA) are rare causative pathogens in infective endocarditis (IE). This study aims to describe the epidemiology, clinical characteristics, and outcome of ABI/GRA-IE. The main features of ABI/GRA-IE were compared with Viridans group streptococci (VGS) IE. From January 2015 to December 2023, a total of 1531 definite IE in Zhongshan Hospital, Fudan University, Shanghai, China were retrospectively enrolled in this study. Clinical and laboratory data were collected. Forty-five ABI/GRA-IE cases were identified, representing 2.9% of all IE cases in Zhongshan Hospital between 2015 and 2023, compared to 20.1% of VGS-IE. ABI and GRA IE shared similar clinical characteristics. Congenital valvulopathy was reported in 21 (46.7%) ABI/GRA-IE and 85 (28.8%) VGS-IE (P = 0.025). Pulmonary valve was more frequently affected in ABI/GRA-IE (6 [13.3%]) than VGS-IE (7 [2.4%]) (P = 0.002). Congestive heart failure was observed in 30 (66.7%) ABI/GRA-IE and 103 (34.9%) VGS-IE (P < 0.001). Systemic embolization excluding central nervous system (CNS) occurred in 13 (28.9%) ABI/GRA-IE and 39 (13.2%) VGS-IE (P = 0.012). In-hospital mortality was reported as 4.4% in ABI/GRA-IE and 3.7% in VGS-IE (P = 0.854). GRA/ABI-IE was approximately one-seventh as prevalent as VGS-IE. Congestive heart failure and systemic embolization (excluding CNS) were more frequent in GRA/ABI-IE compared to VGS-IE. Mortality of ABI/GRA-IE in this study was comparable to that of VGS-IE and lower than previously reported results.
Sections du résumé
BACKGROUND
BACKGROUND
Abiotrophia (ABI) and Granulicatella (GRA) are rare causative pathogens in infective endocarditis (IE). This study aims to describe the epidemiology, clinical characteristics, and outcome of ABI/GRA-IE. The main features of ABI/GRA-IE were compared with Viridans group streptococci (VGS) IE.
METHODS
METHODS
From January 2015 to December 2023, a total of 1531 definite IE in Zhongshan Hospital, Fudan University, Shanghai, China were retrospectively enrolled in this study. Clinical and laboratory data were collected.
RESULTS
RESULTS
Forty-five ABI/GRA-IE cases were identified, representing 2.9% of all IE cases in Zhongshan Hospital between 2015 and 2023, compared to 20.1% of VGS-IE. ABI and GRA IE shared similar clinical characteristics. Congenital valvulopathy was reported in 21 (46.7%) ABI/GRA-IE and 85 (28.8%) VGS-IE (P = 0.025). Pulmonary valve was more frequently affected in ABI/GRA-IE (6 [13.3%]) than VGS-IE (7 [2.4%]) (P = 0.002). Congestive heart failure was observed in 30 (66.7%) ABI/GRA-IE and 103 (34.9%) VGS-IE (P < 0.001). Systemic embolization excluding central nervous system (CNS) occurred in 13 (28.9%) ABI/GRA-IE and 39 (13.2%) VGS-IE (P = 0.012). In-hospital mortality was reported as 4.4% in ABI/GRA-IE and 3.7% in VGS-IE (P = 0.854).
CONCLUSION
CONCLUSIONS
GRA/ABI-IE was approximately one-seventh as prevalent as VGS-IE. Congestive heart failure and systemic embolization (excluding CNS) were more frequent in GRA/ABI-IE compared to VGS-IE. Mortality of ABI/GRA-IE in this study was comparable to that of VGS-IE and lower than previously reported results.
Identifiants
pubmed: 39304837
doi: 10.1186/s12879-024-09943-4
pii: 10.1186/s12879-024-09943-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1022Subventions
Organisme : National Natural Science Foundation of China
ID : NSFC82072325
Organisme : Zhongshan Hospital of Fudan University
ID : 2023ZSQN11
Informations de copyright
© 2024. The Author(s).
Références
Alberti MO, Hindler JA, Humphries RM. Antimicrobial susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans. Antimicrob Agents Chemother. 2016;60:1411–20.
doi: 10.1128/AAC.02645-15
pmcid: 4776019
Téllez A, Ambrosioni J, Llopis J, Pericàs JM, Falces C, Almela M, et al. Epidemiology, clinical features, and Outcome of Infective endocarditis due to Abiotrophia Species and Granulicatella species: Report of 76 cases, 2000–2015. Clin Infect Dis. 2017;66:104–11.
doi: 10.1093/cid/cix752
Cargill JS, Scott KS, Gascoyne-Binzi D, Sandoe JAT. Granulicatella infection: diagnosis and management. J Méd Microbiol. 2012;61 Pt6:755–61.
Senn L, Entenza JM, Greub G, Jaton K, Wenger A, Bille J, et al. Bloodstream and endovascular infections due to Abiotrophia defectiva and granulicatellaspecies. BMC Infect Dis. 2006;6:9.
doi: 10.1186/1471-2334-6-9
pubmed: 16426445
pmcid: 1360077
García-Granja PE, López J, Vilacosta I, Sarriá C, Ladrón R, Olmos C, et al. Nutritionally variant Streptococci Infective endocarditis: a different view. Clin Infect Dis. 2018;67:1800–1.
pubmed: 29788249
Delgado V, Marsan NA, de Waha S, Bonaros N, Brida M, Burri H, et al. 2023 ESC guidelines for the management of endocarditis. Eur Hear J. 2023;44:3948–4042.
doi: 10.1093/eurheartj/ehad193
Iung B, Duval X. Infective endocarditis: innovations in the management of an old disease. Nat Rev Cardiol. 2019;16:623–35.
doi: 10.1038/s41569-019-0215-0
pubmed: 31175343
Cahill TJ, Baddour LM, Habib G, Hoen B, Salaun E, Pettersson GB, et al. Challenges in Infective Endocarditis. J Am Coll Cardiol. 2017;69:325–44.
doi: 10.1016/j.jacc.2016.10.066
pubmed: 28104075
Brouqui P, Raoult D. Endocarditis due to Rare and fastidious Bacteria. Clin Microbiol Rev. 2001;14:177–207.
doi: 10.1128/CMR.14.1.177-207.2001
pubmed: 11148009
pmcid: 88969
Téllez A, Ambrosioni J, Hernández-Meneses M, Llopis J, Ripa M, Chambers ST, et al. Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group Streptococci. J Infect. 2022;85:137–46.
doi: 10.1016/j.jinf.2022.05.023
pubmed: 35618152
Fowler VG, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis AL, et al. The 2023 Duke-International Society for Cardiovascular Infectious diseases Criteria for Infective endocarditis: updating the modified Duke Criteria. Clin Infect Dis. 2023;77:518–26.
doi: 10.1093/cid/ciad271
pubmed: 37138445
pmcid: 10681650
Berge A, Kronberg K, Sunnerhagen T, Nilson BHK, Giske CG, Rasmussen M. Risk for endocarditis in bacteremia with Streptococcus-like bacteria, a retrospective population-based cohort study. Open Forum Infect Dis. 2019;6:ofz437.
doi: 10.1093/ofid/ofz437
pubmed: 31667201
pmcid: 6814282
García-Granja PE, Ladrón R, López J. Nutritionally variant streptococci infective endocarditis: report of 5 cases. Med Clínica. 2019;152:201–2.
doi: 10.1016/j.medcli.2018.04.002
Adam EL, Siciliano RF, Gualandro DM, Calderaro D, Issa VS, Rossi F, et al. Case series of infective endocarditis caused by Granulicatella species. Int J Infect Dis. 2015;31:56–8.
doi: 10.1016/j.ijid.2014.10.023
pubmed: 25461651
Tattevin P, Watt G, Revest M, Arvieux C, Fournier P-E. Update on blood culture-negative endocarditis. Médecine Mal Infect. 2015;45:1–8.
doi: 10.1016/j.medmal.2014.11.003
Chesdachai S, Yetmar ZA, Tabaja H, Comba IY, Go JR, Challener DW, et al. Contemporary experience of Abiotrophia, Granulicatella and Gemella bacteremia. J Infect. 2022;84:511–7.
doi: 10.1016/j.jinf.2022.01.039
pubmed: 35114301
Cañas MA, Téllez A, Mària CG, de la, Dahl A, García-González J, Hernández-Meneses M, et al. Development of high-level Daptomycin Resistance in Abiotrophia and Granulicatella Species isolates from patients with infective endocarditis. Antimicrob Agents Chemother. 2021;65:e02522–20.
doi: 10.1128/AAC.02522-20
pubmed: 34252304
pmcid: 8448108
Mushtaq A, Greenwood-Quaintance KE, Cole NC, Kohner PC, Ihde SM, Strand GJ, et al. Differential Antimicrobial susceptibilities of Granulicatella adiacens and Abiotrophia defectiva. Antimicrob Agents Chemother. 2016;60:5036–9.
doi: 10.1128/AAC.00485-16
pubmed: 27216060
pmcid: 4958207
Prasidthrathsint K, Fisher MA. Antimicrobial susceptibility patterns among a large, nationwide cohort of Abiotrophia and Granulicatella Clinical isolates. J Clin Microbiol. 2016;55:1025–31.
doi: 10.1128/JCM.02054-16
Bouvet A. Human endocarditis due to nutritionally variant streptococci: Streptococcus adjacens and Streptococcus defectivus. Eur Hear J. 1995;16:24–7.
doi: 10.1093/eurheartj/16.suppl_B.24
Estévez A, Marín M, Sánchez-Carrillo C, Machado M, Alcalá L, Pinilla B, et al. Abiotrophia spp. and Granulicatella Spp. Infective endocarditis: a contemporary perspective. Front Biosci-Elite. 2022;14:23.
doi: 10.31083/j.fbe1403023