Enantioselectivity in Vanadium-Dependent Haloperoxidases of Different Marine Sources for Sulfide Oxidation to Sulfoxides.

Oxidation-Reduction Sulfides / metabolism Stereoisomerism Vanadium / chemistry Aquatic Organisms Sulfoxides / chemistry Molecular Docking Simulation Molecular Dynamics Simulation Rhodophyta / enzymology Peroxidases / metabolism Hydrogen Peroxide / metabolism Phaeophyceae
biocatalysts enantioselectivity oxidation pathway sulfoxidation vanadium haloperoxidase

Journal

Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729

Informations de publication

Date de publication:
14 Sep 2024
Historique:
received: 20 08 2024
revised: 13 09 2024
accepted: 13 09 2024
medline: 27 9 2024
pubmed: 27 9 2024
entrez: 27 9 2024
Statut: epublish

Résumé

This study explores the reasons behind the variations in the enantioselectivity of the sulfoxidation of methyl phenyl sulfide by marine-derived vanadium-dependent haloperoxidases (VHPOs). Twelve new VHPOs of marine organisms were overexpressed, purified, and tested for their ability to oxidize sulfide. Most of these marine enzymes exhibited nonenantioselective behavior, underscoring the uniqueness of

Identifiants

DOI: 10.3390/md22090419 PMID: 39330300
pubmed: 39330300
pii: md22090419
doi: 10.3390/md22090419
pii:
doi:

Substances chimiques

Sulfides 0
Vanadium 00J9J9XKDE
Sulfoxides 0
methylphenylsulfide BB4K737YF4
Peroxidases EC 1.11.1.-
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Yun-Han Zhang (YH)

School of Marine Sciences, Sun Yat-sen University, Zhuhai 519080, China.
ORCID: 0009-0004-9093-5965

Ya-Ting Zou (YT)

School of Marine Sciences, Sun Yat-sen University, Zhuhai 519080, China.

Yong-Yi Zeng (YY)

School of Marine Sciences, Sun Yat-sen University, Zhuhai 519080, China.
ORCID: 0000-0001-5300-1945

Lan Liu (L)

School of Marine Sciences, Sun Yat-sen University, Zhuhai 519080, China.
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519080, China.
ORCID: 0000-0003-2765-4015

Bi-Shuang Chen (BS)

School of Marine Sciences, Sun Yat-sen University, Zhuhai 519080, China.
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519080, China.
ORCID: 0000-0002-7221-1208

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfures › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Vanadium › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Phénomènes biologiques › Phénomènes écologiques et environnementaux › Eaux salées › Eau de mer › Organismes aquatiques › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfoxydes › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Eucaryotes › Rhodophyta › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Enantioselectivity in Vanadium-Dependent...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Enantioselectivity in Vanadium-Dependent...