Toxicity Profile of eBAT, a Bispecific Ligand-Targeted Toxin Directed to EGFR and uPAR, in Mice and a Clinical Dog Model.

Animals Dogs Receptors, Urokinase Plasminogen Activator / metabolism ErbB Receptors / metabolism Female Mice, Knockout Mice Mice, Inbred C57BL Sarcoma / drug therapy Antineoplastic Agents / toxicity Urokinase-Type Plasminogen Activator / genetics Epidermal Growth Factor Male Ligands
immunotoxin pharmacology sarcoma targeted therapy toxicity

Journal

Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765

Informations de publication

Date de publication:
26 Aug 2024
Historique:
received: 25 04 2024
revised: 15 07 2024
accepted: 20 08 2024
medline: 27 9 2024
pubmed: 27 9 2024
entrez: 27 9 2024
Statut: epublish

Résumé

EGFR-targeted therapies are efficacious, but toxicity is common and can be severe. Urokinase type plasminogen activator receptor (uPAR)-targeted drugs are only emerging, so neither their efficacy nor toxicity is fully established. Recombinant eBAT was created by combining cytokines EGF and uPA on the same single-chain molecule with truncated

Identifiants

DOI: 10.3390/toxins16090376 PMID: 39330834
pubmed: 39330834
pii: toxins16090376
doi: 10.3390/toxins16090376
pii:
doi:

Substances chimiques

Receptors, Urokinase Plasminogen Activator 0
ErbB Receptors EC 2.7.10.1
Antineoplastic Agents 0
Urokinase-Type Plasminogen Activator EC 3.4.21.73
Epidermal Growth Factor 62229-50-9
Ligands 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : 1K01TW171420-23A1
Pays : United States

Auteurs

Rose H Dicovitsky (RH)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Jill T Schappa (JT)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Experimental Surgical Services, Department of Surgery, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.

Ashley J Schulte (AJ)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

Haeree P Lang (HP)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Comparative Molecular Biosciences Graduate Program and DVM-PhD Dual Degree Program, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Ellen Kuerbitz (E)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Sarah Roberts (S)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Taylor A DePauw (TA)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Microbiology, Immunology, and Cancer Biology Graduate Program, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
ORCID: 0009-0006-5235-753X

Mitzi Lewellen (M)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

Amber L Winter (AL)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Clinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Kathy Stuebner (K)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Clinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Michelle Buettner (M)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Clinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Kelly Reid (K)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Clinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Kelly Bergsrud (K)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Clinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Sara Pracht (S)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Clinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Andrea Chehadeh (A)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Clinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Caitlin Feiock (C)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Clinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

M Gerard O'Sullivan (MG)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Tim Carlson (T)

Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.

Alexandra R Armstrong (AR)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
ORCID: 0000-0002-8498-2843

Danielle Meritet (D)

Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.
ORCID: 0000-0003-4445-7291

Michael S Henson (MS)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

Brenda J Weigel (BJ)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.

Jaime F Modiano (JF)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Institute for Engineering in Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
ORCID: 0000-0001-6398-7648

Antonella Borgatti (A)

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Clinical Investigation Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
ORCID: 0000-0003-1939-0611

Daniel A Vallera (DA)

Animal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Department of Radiation Oncology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
ORCID: 0000-0003-4587-3238

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à l'activateur du plasminogène de type urokinase › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Activateurs du plasminogène › Activateur du plasminogène de type urokinase › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la famille de l'EGF › Facteur de croissance épidermique › Toxicity Profile of eBAT, a Bispecific...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Toxicity Profile of eBAT, a Bispecific...