Enzymatic Hydrolysis of Resorcylic Acid Lactones by an

Zearalenone / metabolism Hydrolysis Lactones / metabolism Macrolides / metabolism Hydrolases / metabolism
Aeromicrobium sp. HZEN biotransformation heat shock protein 90 (Hsp90) radicicol resorcylic acid lactone zearalenone α/β-hydrolase

Journal

Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765

Informations de publication

Date de publication:
19 Sep 2024
Historique:
received: 19 07 2024
revised: 04 09 2024
accepted: 13 09 2024
medline: 27 9 2024
pubmed: 27 9 2024
entrez: 27 9 2024
Statut: epublish

Résumé

Zearalenone and radicicol are resorcylic acid lactones produced by numerous plant pathogenic fungi. Zearalenone is a non-steroidal estrogen mimic that can cause serious reproductive issues in livestock that consume contaminated feed. Radicicol is a potent inhibitor of the molecular chaperone Hsp90, which, in plants, has an important role in coordinating the host's immune response during infection. Here, we describe the identification and characterization of a soil-borne strain of the Gram-positive bacterium

Identifiants

DOI: 10.3390/toxins16090404 PMID: 39330862
pubmed: 39330862
pii: toxins16090404
doi: 10.3390/toxins16090404
pii:
doi:

Substances chimiques

Zearalenone 5W827M159J
Lactones 0
monorden I60EH8GECX
Macrolides 0
Hydrolases EC 3.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Agriculture & Agri-Food Canada
ID : CAP-ASP-110, SCAP-ASP-026, CRDA J-002398

Auteurs

Shawn J Hoogstra (SJ)

London Research and Development Center, Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.
ORCID: 0000-0003-2533-9310

Kyle N Hendricks (KN)

London Research and Development Center, Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.
Department of Biology, Western University, London, ON N6A 3K7, Canada.
ORCID: 0000-0003-2303-2438

David R McMullin (DR)

Department of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
ORCID: 0000-0001-9808-924X

Justin B Renaud (JB)

London Research and Development Center, Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.

Juhi Bora (J)

London Research and Development Center, Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.

Mark W Sumarah (MW)

London Research and Development Center, Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.
ORCID: 0000-0003-0977-1656

Christopher P Garnham (CP)

London Research and Development Center, Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Mycotoxines › Zéaralénone › Enzymatic Hydrolysis of Resorcylic Acid Lactones by an
questionsmedicales.fr › Phénomènes chimiques › Hydrolyse › Enzymatic Hydrolysis of Resorcylic Acid Lactones by an
questionsmedicales.fr › Composés chimiques organiques › Lactones › Enzymatic Hydrolysis of Resorcylic Acid Lactones by an
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Enzymatic Hydrolysis of Resorcylic Acid Lactones by an
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Enzymatic Hydrolysis of Resorcylic Acid Lactones by an