Effect of post-mating administration of ketoprofen on serum progesterone concentration and fertility in Akkaraman ewes.
Animals
Progesterone
/ blood
Female
Ketoprofen
/ administration & dosage
Fertility
/ drug effects
Pregnancy
Anti-Inflammatory Agents, Non-Steroidal
/ administration & dosage
Estrus Synchronization
Pregnancy Rate
Sheep
/ blood
Injections, Intramuscular
/ veterinary
Random Allocation
Litter Size
/ drug effects
Embryonic
Ewes fertility
Ketoprofen
Mortality
Progesterone
Journal
Tropical animal health and production
ISSN: 1573-7438
Titre abrégé: Trop Anim Health Prod
Pays: United States
ID NLM: 1277355
Informations de publication
Date de publication:
27 Sep 2024
27 Sep 2024
Historique:
received:
15
01
2024
accepted:
11
09
2024
medline:
27
9
2024
pubmed:
27
9
2024
entrez:
27
9
2024
Statut:
epublish
Résumé
A major cause of early embryonic losses is inadequate secretion of progesterone (P4) hormone due to luteal insufficiency in farm animals. Post-mating applications that directly or indirectly increasing serum P4 concentrations have a positive effect on fertility. The aim of this study was to investigate the effect of post-mating administration of ketoprofen on serum P4 concentration and fertility in Akkaraman ewes synchronized with a short-term protocol during the breeding season. Oestrus monitoring ewes after synchronization were hand-mated and randomly assigned to two equal groups (Ketoprofen vs. Control). Ewes in the ketoprofen group (KPG) (n = 40) were administered with ketoprofen (Rifen, Richter pharma, Austria) intramuscularly (im) at a dose of 3 mg/kg on days 9 and 10 after mating. In the control group (CG) ewes (n = 40) were administered with saline im on the same days. Blood samples were collected from ewes in both groups at four different time points of post-mating days (9, 12, 15 and 18 days). The results showed that there were no statistical differences between the KPG and CG groups on fertility parameters; pregnancy rates (85% vs. 72.5%), lambing rates (100% vs. 100%), single birth rates (55.9% vs. 55.2%), multiple birth rates (44.1% vs. 44.8%), litter sizes (1.56 vs. 1.55). In pregnant ewes, serum P4 concentrations on day 18 (4.35 ± 0.34 ng/mL) in the KPG group were higher than (3.27 ± 0.27 ng/mL) in CG group (P < 0.05). It was concluded that post-mating ketoprofen administration have no significant effect on fertility, but significantly increased the serum P4 concentration on day 18 in pregnant ewes.
Identifiants
pubmed: 39331175
doi: 10.1007/s11250-024-04156-y
pii: 10.1007/s11250-024-04156-y
doi:
Substances chimiques
Progesterone
4G7DS2Q64Y
Ketoprofen
90Y4QC304K
Anti-Inflammatory Agents, Non-Steroidal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
291Subventions
Organisme : Selçuk University Research Foundation
ID : 20203013
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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