Poly ADP-ribose signaling is dysregulated in Huntington disease.

Humans Huntington Disease / metabolism Huntingtin Protein / metabolism Poly Adenosine Diphosphate Ribose / metabolism Signal Transduction DNA Damage Neurons / metabolism Induced Pluripotent Stem Cells / metabolism Fibroblasts / metabolism DNA Repair
Huntington’s disease PARP1 PARylation huntingtin poly ADP-ribose

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
Oct 2024
Historique:
medline: 27 9 2024
pubmed: 27 9 2024
entrez: 27 9 2024
Statut: ppublish

Résumé

Huntington disease (HD) is a genetic neurodegenerative disease caused by cytosine, adenine, guanine (CAG) expansion in the

Identifiants

DOI: 10.1073/pnas.2318098121 PMID: 39331414
pubmed: 39331414
doi: 10.1073/pnas.2318098121
doi:

Substances chimiques

Huntingtin Protein 0
Poly Adenosine Diphosphate Ribose 26656-46-2
HTT protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2318098121

Subventions

Organisme : Canadian Government | Canadian Institutes of Health Research (CIHR)
ID : PJT-168966
Organisme : Canadian Government | Canadian Institutes of Health Research (CIHR)
ID : PJT-180258
Organisme : NINDS NIH HHS
ID : R37 NS067525
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS067525
Pays : United States
Organisme : HHS | NIH (NIH)
ID : T32GM080189
Organisme : HHS | NIH (NIH)
ID : T32-CA009110
Organisme : NINDS NIH HHS
ID : R35 NS116872
Pays : United States
Organisme : UKRI | MRC | Medical Research Council Centre for Neurodevelopmental Disorders (CNDD)
ID : MR/M008592/1
Organisme : CHDI Foundation (CHDI)
ID : CHDI002

Déclaration de conflit d'intérêts

Competing interests statement:E.J.W. reports consultancy/ advisory board memberships with Annexon, Remix Therapeutics, Hoffman La Roche Ltd., Ionis Pharmaceuticals, PTC Therapeutics, Takeda, Teitur Trophics, Triplet Therapeutics and Vico Therapeutics. All honoraria for these consultancies were paid through the offices of UCL Consultants Ltd., a wholly owned subsidiary of University College London. F.B.R. is a Medpace UK Ltd. employee and was a University College London employee during the conduct of this study. F.B.R. has provided consultancy services to GLG and F. Hoffmann-La Roche Ltd. L.M.B. currently holds consultancy contracts with Annexon Biosciences, Remix Therapeutics, and LoQus23 Therapeutics Ltd. via UCL Consultants Ltd. R.T. has past consultancy with Novartis AG, PTC Therapeutics and Mitokinin LLC.

Auteurs

Tamara Maiuri (T)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.
ORCID: 0000-0002-6103-5835

Carlos Barba Bazan (CB)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.
ORCID: 0000-0002-1884-5760

Rachel J Harding (RJ)

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto ON M5S 3M2, Canada.
Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
ORCID: 0000-0002-1134-391X

Nola Begeja (N)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.
ORCID: 0000-0002-9805-8037

Tae-In Kam (TI)

Neurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
ORCID: 0000-0002-7241-4902

Lauren M Byrne (LM)

University College London Huntington Disease Centre, University College London Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
ORCID: 0000-0003-1650-4273

Filipe B Rodrigues (FB)

University College London Huntington Disease Centre, University College London Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
ORCID: 0000-0002-5567-7938

Monica M Warner (MM)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.
Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
ORCID: 0000-0001-7951-9662

Kaitlyn Neuman (K)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.
ORCID: 0000-0001-7699-9680

Muqtasid Mansoor (M)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.
ORCID: 0000-0001-8192-6590

Mohsen Badiee (M)

Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
ORCID: 0000-0003-3722-4609

Morgan Dasovich (M)

Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
ORCID: 0001-0000-7951-9662

Keona Wang (K)

Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
ORCID: 0000-0002-7715-2489

Leslie M Thompson (LM)

Department of Neurobiology and Behavior, University of California, Irvine, CA 92697.
Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92868.
ORCID: 0000-0003-4573-9514

Anthony K L Leung (AKL)

Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.
Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
ORCID: 0000-0001-5569-4036

Sara N Andres (SN)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.
Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4L8, Canada.
ORCID: 0000-0002-4795-2856

Edward J Wild (EJ)

University College London Huntington Disease Centre, University College London Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
ORCID: 0000-0002-6921-7887

Ted M Dawson (TM)

Neurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
ORCID: 0000-0002-6459-0893

Valina L Dawson (VL)

Neurodegeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
ORCID: 0000-0002-2915-3970

Cheryl H Arrowsmith (CH)

Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 1L7, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
ORCID: 0000-0002-4971-3250

Ray Truant (R)

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.
ORCID: 0000-0003-2542-6641

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Poly ADP-ribose signaling is dysregulated in...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie de Huntington › Poly ADP-ribose signaling is dysregulated in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéine huntingtine › Poly ADP-ribose signaling is dysregulated in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléoside diphosphate ose › Adénosine diphosphate ose › Adénosine diphosphate ribose › Poly adénosine diphosphate ribose › Poly ADP-ribose signaling is dysregulated in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Poly ADP-ribose signaling is dysregulated in...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Poly ADP-ribose signaling is dysregulated in...
questionsmedicales.fr › Cellules › Neurones › Poly ADP-ribose signaling is dysregulated in...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Poly ADP-ribose signaling is dysregulated in...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Poly ADP-ribose signaling is dysregulated in...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Poly ADP-ribose signaling is dysregulated in...