Endothelial force sensing signals to parenchymal cells to regulate bile and plasma lipids.
Animals
Mice
Ion Channels
/ metabolism
Nitric Oxide Synthase Type III
/ metabolism
Humans
Hepatocytes
/ metabolism
Cholesterol 7-alpha-Hydroxylase
/ metabolism
Nitric Oxide
/ metabolism
Bile Acids and Salts
/ metabolism
Bile
/ metabolism
Lipid Metabolism
Liver
/ metabolism
Lipids
/ blood
Cholesterol
/ metabolism
Endothelium
/ metabolism
Endothelial Cells
/ metabolism
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
27 Sep 2024
27 Sep 2024
Historique:
medline:
27
9
2024
pubmed:
27
9
2024
entrez:
27
9
2024
Statut:
ppublish
Résumé
How cardiovascular activity interacts with lipid homeostasis is incompletely understood. We postulated a role for blood flow acting at endothelium in lipid regulatory organs. Transcriptome analysis was performed on livers from mice engineered for deletion of the flow-sensing PIEZO1 channel in endothelium. This revealed unique up-regulation of
Identifiants
pubmed: 39331703
doi: 10.1126/sciadv.adq3075
doi:
Substances chimiques
Ion Channels
0
Nitric Oxide Synthase Type III
EC 1.14.13.39
Cholesterol 7-alpha-Hydroxylase
EC 1.14.14.23
Nitric Oxide
31C4KY9ESH
Bile Acids and Salts
0
Piezo1 protein, mouse
0
Cyp7a1 protein, mouse
EC 1.14.14.23
Lipids
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM