Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy.

Animals CD8-Positive T-Lymphocytes / immunology Antigens, Ly / metabolism Mice Immunotherapy / methods Tumor Microenvironment / immunology Mice, Inbred C57BL Cell Line, Tumor Humans Melanoma, Experimental / immunology Female Programmed Cell Death 1 Receptor / metabolism Skin Neoplasms / immunology Mitochondria / metabolism Melanoma / immunology Interferon Type I / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
27 Sep 2024
Historique:
received: 13 06 2023
accepted: 25 08 2024
medline: 28 9 2024
pubmed: 28 9 2024
entrez: 27 9 2024
Statut: epublish

Résumé

T cell inhibitory mechanisms prevent autoimmune reactions, while cancer immunotherapy aims to remove these inhibitory signals. Chronic ultraviolet (UV) exposure attenuates autoimmunity through promotion of poorly understood immune-suppressive mechanisms. Here we show that mice with subcutaneous melanoma are not responsive to anti-PD1 immunotherapy following chronic UV irradiation, given prior to tumor injection, due to the suppression of T cell killing ability in skin-draining lymph nodes. Using mass cytometry and single-cell RNA-sequencing analyzes, we discover that skin-specific, UV-induced suppression of T-cells killing activity is mediated by upregulation of a Ly6a

Identifiants

DOI: 10.1038/s41467-024-52079-x PMID: 39333093
pubmed: 39333093
doi: 10.1038/s41467-024-52079-x
pii: 10.1038/s41467-024-52079-x
doi:

Substances chimiques

Antigens, Ly 0
Programmed Cell Death 1 Receptor 0
Interferon Type I 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8354

Informations de copyright

© 2024. The Author(s).

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Auteurs

Avishai Maliah (A)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Nadine Santana-Magal (N)

Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Shivang Parikh (S)

The Ragon Institute of Mass General, MIT and Harvard 600/625 Main Street, Cambridge, MA, USA.
ORCID: 0000-0001-6364-9307

Sagi Gordon (S)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Keren Reshef (K)

Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Yuval Sade (Y)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Aseel Khateeb (A)

Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Alon Richter (A)

Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0009-0004-7126-7981

Amit Gutwillig (A)

Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Roma Parikh (R)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Tamar Golan (T)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Matan Krissi (M)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Manho Na (M)

Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Gal Binshtok (G)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Paulee Manich (P)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0000-0002-0484-6543

Nadav Elkoshi (N)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Sharon Grisaru-Tal (S)

Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0000-0003-3530-308X

Valentina Zemser-Werner (V)

Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Ronen Brenner (R)

Institute of Oncology, E. Wolfson Medical Center, Holon, Israel.

Hananya Vaknine (H)

Institute of Pathology, E. Wolfson Medical Center, Holon, Israel.

Eran Nizri (E)

Peritoneal Surface Malignancies and Melanoma Unit, Department of Surgery A, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Lilach Moyal (L)

Felsenstein Medical Research Center, Tel-Aviv University and the Division of Dermatology, Rabin Medical Center, Petach Tikva, Israel.

Iris Amitay-Laish (I)

Felsenstein Medical Research Center, Tel-Aviv University and the Division of Dermatology, Rabin Medical Center, Petach Tikva, Israel.

Luiza Rosemberg (L)

School of Zoology, Tel Aviv University, Tel Aviv-Yafo, Israel.

Ariel Munitz (A)

Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0000-0003-1626-3019

Noga Kronfeld-Schor (N)

School of Zoology, Tel Aviv University, Tel Aviv-Yafo, Israel.
ORCID: 0000-0002-5224-3341

Eric Shifrut (E)

Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Faculty of Life Sciences, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel.
Dotan Center for Advanced Therapies, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Oren Kobiler (O)

Department of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
ORCID: 0000-0001-9914-3770

Asaf Madi (A)

Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Tamar Geiger (T)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
ORCID: 0000-0002-9526-197X

Yaron Carmi (Y)

Department of Pathology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. yaroncarmi@tauex.tau.ac.il.
ORCID: 0000-0002-0972-0616

Carmit Levy (C)

Department of Human Genetics and Biochemistry, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. carmitlevy@tauex.tau.ac.il.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes Ly › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Tumeurs expérimentales › Mélanome expérimental › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Crosslinking of Ly6a metabolically reprograms...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Crosslinking of Ly6a metabolically reprograms...