Neuromodulation and mindfulness as therapeutic treatment in detoxified patients with alcohol use disorder.
Humans
Mindfulness
/ methods
Alcoholism
/ therapy
Adult
Vagus Nerve Stimulation
/ methods
Transcranial Direct Current Stimulation
/ methods
Male
Craving
/ physiology
Female
Transcutaneous Electric Nerve Stimulation
/ methods
Theta Rhythm
/ physiology
Secondary Prevention
Combined Modality Therapy
Middle Aged
Cues
Alcohol use disorder
Closed-loop amplitude-modulated transcranial alternating current stimulation
Cognitive control
Cue reactivity
Electroencephalography
Frontal midline theta
Heart rate variability
Interception
Mindfulness-based relapse prevention
Neuromodulation
Vagus nerve stimulation
Journal
BMC psychiatry
ISSN: 1471-244X
Titre abrégé: BMC Psychiatry
Pays: England
ID NLM: 100968559
Informations de publication
Date de publication:
27 Sep 2024
27 Sep 2024
Historique:
received:
11
06
2024
accepted:
14
09
2024
medline:
28
9
2024
pubmed:
28
9
2024
entrez:
28
9
2024
Statut:
epublish
Résumé
Alcohol use disorder (AUD) poses a significant global health challenge. Traditional management strategies often face high relapse rates, leading to a need for innovative approaches. Mindfulness-based relapse prevention (MBRP) has emerged as a promising intervention to enhance cognitive control, reduce cue-related craving and improve interoceptive processing. Neuroimaging studies suggest that mindfulness training can modulate brain networks associated with these factors, potentially improving treatment outcomes for AUD. Neuroimaging studies suggest that mindfulness training can modulate brain networks linked to these brain functions, potentially improving treatment outcomes for AUD. However, it is unclear how MBRP links to neurophysiological measures such as frontal midline theta oscillations (FMΘ) and whether the beneficial effects of MBRP can be increased by enhancing FMΘ. Here, we will use two different forms of neuromodulation to target and enhance these oscillations, and evaluate their impact on the effectiveness of MBRP. This study will employ a four-arm randomized controlled trial to evaluate the synergistic effects of MBRP augmented with transcutaneous vagus nerve stimulation (tVNS) or closed-loop amplitude-modulated transcranial alternating current stimulation (CLAM-tACS) on cognitive control, cue reactivity and interoceptive processing in AUD patients. Participants will undergo six weekly group MBRP sessions and daily individual mindfulness practices. Assessments will include an inhibition task, cue-induced craving task, and heartbeat discrimination task, alongside heart rate variability and 32-channel EEG recordings. Participants will be assessed pre and post treatment, with a three-month follow-up to evaluate long-term effects on abstinence and alcohol consumption. This study will not only elucidate the causal link between FMΘ and efficacy of MBRP, but contribute to a better understanding of how combined psychological and neuromodulation interventions can improve treatment outcomes for AUD, potentially leading to more effective therapeutic strategies. This study also seeks to explore individual differences in response to treatment, which could inform future approaches to AUD management. This study received approval by the Charité-Universitätsmedizin Berlin Institutional Review Board (EA1/030/23, 10.11.2023). It was registered on ClinicalTrials.gov (NCT06308484).
Sections du résumé
BACKGROUND
BACKGROUND
Alcohol use disorder (AUD) poses a significant global health challenge. Traditional management strategies often face high relapse rates, leading to a need for innovative approaches. Mindfulness-based relapse prevention (MBRP) has emerged as a promising intervention to enhance cognitive control, reduce cue-related craving and improve interoceptive processing. Neuroimaging studies suggest that mindfulness training can modulate brain networks associated with these factors, potentially improving treatment outcomes for AUD. Neuroimaging studies suggest that mindfulness training can modulate brain networks linked to these brain functions, potentially improving treatment outcomes for AUD. However, it is unclear how MBRP links to neurophysiological measures such as frontal midline theta oscillations (FMΘ) and whether the beneficial effects of MBRP can be increased by enhancing FMΘ. Here, we will use two different forms of neuromodulation to target and enhance these oscillations, and evaluate their impact on the effectiveness of MBRP.
METHODS
METHODS
This study will employ a four-arm randomized controlled trial to evaluate the synergistic effects of MBRP augmented with transcutaneous vagus nerve stimulation (tVNS) or closed-loop amplitude-modulated transcranial alternating current stimulation (CLAM-tACS) on cognitive control, cue reactivity and interoceptive processing in AUD patients. Participants will undergo six weekly group MBRP sessions and daily individual mindfulness practices. Assessments will include an inhibition task, cue-induced craving task, and heartbeat discrimination task, alongside heart rate variability and 32-channel EEG recordings. Participants will be assessed pre and post treatment, with a three-month follow-up to evaluate long-term effects on abstinence and alcohol consumption.
DISCUSSION
CONCLUSIONS
This study will not only elucidate the causal link between FMΘ and efficacy of MBRP, but contribute to a better understanding of how combined psychological and neuromodulation interventions can improve treatment outcomes for AUD, potentially leading to more effective therapeutic strategies. This study also seeks to explore individual differences in response to treatment, which could inform future approaches to AUD management.
TRIAL REGISTRATION
BACKGROUND
This study received approval by the Charité-Universitätsmedizin Berlin Institutional Review Board (EA1/030/23, 10.11.2023). It was registered on ClinicalTrials.gov (NCT06308484).
Identifiants
pubmed: 39334026
doi: 10.1186/s12888-024-06085-4
pii: 10.1186/s12888-024-06085-4
doi:
Banques de données
ClinicalTrials.gov
['NCT06308484']
Types de publication
Journal Article
Clinical Trial Protocol
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
635Informations de copyright
© 2024. The Author(s).
Références
World Health Organization. Global status report on alcohol and health 2018. World Health Organization; 2019.
Rehm J, Mathers C, Popova S, Thavorncharoensap M, Teerawattananon Y, Patra J. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet. 2009;373(9682):2223–33.
pubmed: 19560604
doi: 10.1016/S0140-6736(09)60746-7
Grant BF, Chou SP, Saha TD, Pickering RP, Kerridge BT, Ruan WJ, et al. Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001–2002 to 2012–2013: results from the national epidemiologic survey on alcohol and related conditions. JAMA Psychiatry. 2017;74(9):911–23.
pubmed: 28793133
pmcid: 5710229
doi: 10.1001/jamapsychiatry.2017.2161
Degenhardt L, Glantz M, Evans-Lacko S, Sadikova E, Sampson N, Thornicroft G, et al. Estimating treatment coverage for people with substance use disorders: an analysis of data from the world mental health surveys. World Psychiatry. 2017;16(3):299–307.
pubmed: 28941090
pmcid: 5608813
doi: 10.1002/wps.20457
Fleury M-J, Djouini A, Huỳnh C, Tremblay J, Ferland F, Ménard J-M, et al. Remission from substance use disorders: a systematic review and meta-analysis. Drug Alcohol Depend. 2016;168:293–306.
pubmed: 27614380
doi: 10.1016/j.drugalcdep.2016.08.625
Bowen S, Chawla N, Collins SE, Witkiewitz K, Hsu S, Grow J, et al. Mindfulness-based relapse prevention for substance use disorders: a pilot efficacy trial. Subst Abus. 2009;30(4):295–305.
pubmed: 19904665
pmcid: 3280682
doi: 10.1080/08897070903250084
Witkiewitz K, Bowen S, Douglas H, Hsu SH. vol 38, pg 1563,. Mindfulness-based relapse prevention for substance craving (2013). Addict Behav. 2018;82:202-.
Bowen S, Chawla N, Grow J, Marlatt GA. Mindfulness-based relapse prevention for addictive behaviors: a clinician’s guide. Guilford; 2021.
May AC, Davis C, Kirlic N, Stewart JL. Mindfulness-based interventions for the treatment of aberrant interoceptive processing in substance use disorders. Brain Sci. 2022;12(2):279.
pubmed: 35204042
pmcid: 8870441
doi: 10.3390/brainsci12020279
Rosenthal A, Levin ME, Garland EL, Romanczuk-Seiferth N. Mindfulness in treatment approaches for addiction—underlying mechanisms and future directions. Curr Addict Rep. 2021;8(2):282–97.
doi: 10.1007/s40429-021-00372-w
Creswell JD, Taren AA, Lindsay EK, Greco CM, Gianaros PJ, Fairgrieve A, et al. Alterations in resting-state functional connectivity link mindfulness meditation with reduced interleukin-6: a randomized controlled trial. Biol Psychiatry. 2016;80(1):53–61.
pubmed: 27021514
doi: 10.1016/j.biopsych.2016.01.008
Taren AA, Gianaros PJ, Greco CM, Lindsay EK, Fairgrieve A, Brown KW, et al. Mindfulness meditation training and executive control network resting state functional connectivity: a randomized controlled trial. Psychosom Med. 2017;79(6):674–83.
pubmed: 28323668
pmcid: 5489372
doi: 10.1097/PSY.0000000000000466
Tang YY, Askari P, Choi C. Brief mindfulness training increased glutamate metabolism in the anterior cingulate cortex. NeuroReport. 2020;31(16):1142–5.
pubmed: 32991525
doi: 10.1097/WNR.0000000000001527
Tang YY, Lu Q, Geng X, Stein EA, Yang Y, Posner MI. Short-term meditation induces white matter changes in the anterior cingulate. Proc Natl Acad Sci U S A. 2010;107(35):15649–52.
pubmed: 20713717
pmcid: 2932577
doi: 10.1073/pnas.1011043107
Quaglia JT, Zeidan F, Grossenbacher PG, Freeman SP, Braun SE, Martelli A, et al. Brief mindfulness training enhances cognitive control in socioemotional contexts: behavioral and neural evidence. PLoS ONE. 2019;14(7):e0219862.
pubmed: 31323050
pmcid: 6641506
doi: 10.1371/journal.pone.0219862
Pozuelos JP, Mead BR, Rueda MR, Malinowski P. Short-term mindful breath awareness training improves inhibitory control and response monitoring. Prog Brain Res. 2019;244:137–63.
pubmed: 30732835
doi: 10.1016/bs.pbr.2018.10.019
Garland EL, Bryan MA, Priddy SE, Riquino MR, Froeliger B, Howard MO. Effects of mindfulness-oriented recovery enhancement versus social support on negative affective interference during inhibitory control among opioid-treated chronic pain patients: a pilot mechanistic study. Ann Behav Med. 2019;53(10):865–76.
pubmed: 30668631
pmcid: 6735955
doi: 10.1093/abm/kay096
Froeliger B, Mathew AR, McConnell PA, Eichberg C, Saladin ME, Carpenter MJ et al. Restructuring reward mechanisms in nicotine addiction: a pilot fMRI study of mindfulness-oriented recovery enhancement for cigarette smokers. Evidence-Based Complementary and Alternative Medicine. 2017;2017.
Janes AC, Datko M, Roy A, Barton B, Druker S, Neal C, et al. Quitting starts in the brain: a randomized controlled trial of app-based mindfulness shows decreases in neural responses to smoking cues that predict reductions in smoking. Neuropsychopharmacology. 2019;44(9):1631–8.
pubmed: 31039580
pmcid: 6785102
doi: 10.1038/s41386-019-0403-y
Westbrook C, Creswell JD, Tabibnia G, Julson E, Kober H, Tindle HA. Mindful attention reduces neural and self-reported cue-induced craving in smokers. Soc Cognit Affect Neurosci. 2011;8(1):73–84.
doi: 10.1093/scan/nsr076
Strosche A, Zhang XC, Kirsch M, Hermann D, Ende G, Kiefer F et al. Investigation of brain functional connectivity to assess cognitive control over cue-processing in alcohol use disorder. Addict Biol. 2021;26(1).
Stern ER, Grimaldi SJ, Muratore A, Murrough J, Leibu E, Fleysher L, et al. Neural correlates of interoception: effects of interoceptive focus and relationship to dimensional measures of body awareness. Hum Brain Mapp. 2017;38(12):6068–82.
pubmed: 28901713
pmcid: 5757871
doi: 10.1002/hbm.23811
Weng HY, Feldman JL, Leggio L, Napadow V, Park J, Price CJ. Interventions and manipulations of interoception. Trends Neurosci. 2021;44(1):52–62.
pubmed: 33378657
pmcid: 7805576
doi: 10.1016/j.tins.2020.09.010
Jakubczyk A, Trucco EM, Klimkiewicz A, Skrzeszewski J, Suszek H, Zaorska J, et al. Association between interoception and emotion regulation in individuals with alcohol use disorder. Front Psychiatry. 2020;10:1028.
pubmed: 32116829
pmcid: 7008234
doi: 10.3389/fpsyt.2019.01028
Shorey RC, Gawrysiak MJ, Elmquist J, Brem M, Anderson S, Stuart GL. Experiential avoidance, distress tolerance, and substance use cravings among adults in residential treatment for substance use disorders. J Addict Dis. 2017;36(3):151–7.
pubmed: 28358236
pmcid: 6126664
doi: 10.1080/10550887.2017.1302661
Garland EL, Hanley AW, Hudak J, Nakamura Y, Froeliger B. Mindfulness-induced endogenous theta stimulation occasions self-transcendence and inhibits addictive behavior. Sci Adv. 2022;8(41):eabo4455.
pubmed: 36223472
pmcid: 9555770
doi: 10.1126/sciadv.abo4455
Hudak J, Hanley AW, Marchand WR, Nakamura Y, Yabko B, Garland EL. Endogenous theta stimulation during meditation predicts reduced opioid dosing following treatment with mindfulness-oriented recovery enhancement. Neuropsychopharmacology. 2021;46(4):836–43.
pubmed: 32919401
doi: 10.1038/s41386-020-00831-4
Messel MS, Raud L, Hoff PK, Stubberud J, Huster RJ. Frontal-midline theta reflects different mechanisms associated with proactive and reactive control of inhibition. NeuroImage. 2021;241.
Hoper S, Kaess M, Koenig J. Prefrontal cortex oxygenation and autonomic nervous system activity under transcutaneous auricular vagus nerve stimulation in adolescents. Auton Neurosci. 2022;241:103008.
pubmed: 35724559
doi: 10.1016/j.autneu.2022.103008
Keute M, Barth D, Liebrand M, Heinze HJ, Kraemer U, Zaehle T. Effects of transcutaneous vagus nerve stimulation (tVNS) on conflict-related behavioral performance and frontal midline theta activity. J Cogn Enhancement. 2020;4(2):121–30.
doi: 10.1007/s41465-019-00152-5
Richter F, García AM, Rodriguez Arriagada N, Yoris A, Birba A, Huepe D, et al. Behavioral and neurophysiological signatures of interoceptive enhancements following vagus nerve stimulation. Hum Brain Mapp. 2021;42(5):1227–42.
pubmed: 33325575
doi: 10.1002/hbm.25288
Villani V, Tsakiris M, Azevedo RT. Transcutaneous vagus nerve stimulation improves interoceptive accuracy. Neuropsychologia. 2019;134:107201.
pubmed: 31562863
doi: 10.1016/j.neuropsychologia.2019.107201
Konjusha A, Colzato L, Ghin F, Stock AK, Beste C. Auricular transcutaneous vagus nerve stimulation for alcohol use disorder: a chance to improve treatment? Addict Biol. 2022;27(5):e13202.
pubmed: 36001426
doi: 10.1111/adb.13202
Bergmann TO, Hartwigsen G. Inferring causality from noninvasive brain stimulation in cognitive neuroscience. J Cogn Neurosci. 2021;33(2):195–225.
pubmed: 32530381
doi: 10.1162/jocn_a_01591
Kearney-Ramos TE, Dowdle LT, Lench DH, Mithoefer OJ, Devries WH, George MS et al. Transdiagnostic effects of ventromedial prefrontal cortex transcranial magnetic stimulation on cue reactivity. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2018;3(7):599–609.
Kearney-Ramos TE, Dowdle LT, Mithoefer OJ, Devries W, George MS, Hanlon CA. State-dependent effects of ventromedial prefrontal cortex continuous thetaburst stimulation on cocaine cue reactivity in chronic cocaine users. Front Psychiatry. 2019;10.
Nasr K, Haslacher D, Dayan E, Censor N, Cohen LG, Soekadar SR. Breaking the boundaries of interacting with the human brain using adaptive closed-loop stimulation. Prog Neurobiol. 2022;216:102311.
pubmed: 35750290
doi: 10.1016/j.pneurobio.2022.102311
Soekadar SR, Witkowski M, Cossio EG, Birbaumer N, Robinson SE, Cohen LG. In vivo assessment of human brain oscillations during application of transcranial electric currents. Nat Commun. 2013;4:2032.
pubmed: 23787780
doi: 10.1038/ncomms3032
Garcia-Cossio E, Witkowski M, Robinson SE, Cohen LG, Birbaumer N, Soekadar SR. Simultaneous transcranial direct current stimulation (tDCS) and whole-head magnetoencephalography (MEG): assessing the impact of tDCS on slow cortical magnetic fields. NeuroImage. 2016;140:33–40.
pubmed: 26455796
doi: 10.1016/j.neuroimage.2015.09.068
Haslacher D, Nasr K, Robinson SE, Braun C, Soekadar SR. Stimulation artifact source separation (SASS) for assessing electric brain oscillations during transcranial alternating current stimulation (tACS). NeuroImage. 2021;228:117571.
Witkowski M, Garcia-Cossio E, Chander BS, Braun C, Birbaumer N, Robinson SE, et al. Mapping entrained brain oscillations during transcranial alternating current stimulation (tACS). NeuroImage. 2016;140:89–98.
pubmed: 26481671
doi: 10.1016/j.neuroimage.2015.10.024
Haslacher D, Narang A, Cavallo A, Nasr K, Santarnecchi E, Soekadar SR. In-vivo phase-dependent enhancement and suppression of brain oscillations by transcranial alternating current stimulation (tACS). bioRxiv. 2022.
Haslacher D, Nasr K, Robinson SE, Braun C, Soekadar SR. Stimulation artifact source separation (SASS) for assessing electric brain oscillations during transcranial alternating current stimulation (tACS). NeuroImage. 2021;228:117571.
pubmed: 33412281
doi: 10.1016/j.neuroimage.2020.117571
Nasr K, Haslacher D, Dayan E, Censor N, Cohen LG, Soekadar SR. Breaking the boundaries of interacting with the human brain using adaptive closed-loop stimulation. Prog Neurobiol. 2022;216:102311.
Thiele C, Zaehle T, Haghikia A, Ruhnau P. Amplitude modulated transcranial alternating current stimulation (AM-TACS) efficacy evaluation via phosphene induction. Sci Rep-Uk. 2021;11(1).
Koyun AH, Stock A-K, Beste C. Neurophysiological mechanisms underlying the differential effect of reward prospect on response selection and inhibition. Sci Rep-Uk. 2023;13(1):10903.
doi: 10.1038/s41598-023-37524-z
Kuitunen-Paul S, Rehm J, Lachenmeier DW, Kadrić F, Kuitunen PT, Wittchen H-U, et al. Assessment of alcoholic standard drinks using the Munich composite international diagnostic interview (M-CIDI): an evaluation and subsequent revision. Int J Methods Psychiatr Res. 2017;26(3):e1563.
pubmed: 28370786
pmcid: 6877198
doi: 10.1002/mpr.1563
Ross HE, Gavin DR, Skinner HA. Diagnostic validity of the MAST and the alcohol dependence scale in the assessment of DSM-III alcohol disorders. J Stud Alcohol. 1990;51(6):506–13.
pubmed: 2270059
doi: 10.15288/jsa.1990.51.506
Drummond DC, Phillips TS. Alcohol urges in alcohol-dependent drinkers: further validation of the alcohol urge questionnaire in an untreated community clinical population. Addiction. 2002;97(11):1465–72.
pubmed: 12410786
doi: 10.1046/j.1360-0443.2002.00252.x
Anton RF, Moak DH, Latham PK. The obsessive compulsive drinking scale: a new method of assessing outcome in alcoholism treatment studies. Arch Gen Psychiatry. 1996;53(3):225–31.
pubmed: 8611059
doi: 10.1001/archpsyc.1996.01830030047008
Meyer TD, Hautzinger M. Allgemeine Depressions-Skala (ADS). Normierung an Minderjährigen und Erweiterung zur Erfassung manischer Symptome (ADMS). Diagnostica. 2001.
Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Personal Soc Psychol. 1988;54(6):1063.
doi: 10.1037/0022-3514.54.6.1063
Marteau TM, Bekker H. The development of a six-item short‐form of the state scale of the Spielberger State—trait anxiety inventory (STAI). Br J Clin Psychol. 1992;31(3):301–6.
pubmed: 1393159
doi: 10.1111/j.2044-8260.1992.tb00997.x
Spinella M. Normative data and a short form of the Barratt impulsiveness scale. Int J Neurosci. 2007;117(3):359–68.
pubmed: 17365120
doi: 10.1080/00207450600588881
Petrowski K, Paul S, Albani C, Brähler E. Factor structure and psychometric properties of the trier inventory for chronic stress (TICS) in a representative German sample. BMC Med Res Methodol. 2012;12:1–10.
doi: 10.1186/1471-2288-12-42
Cohen S, Kamarck T, Mermelstein R. Perceived stress scale. Measuring Stress: Guide Health Social Scientists. 1994;10(2):1–2.
Heidenreich T, Ströhle G, Michalak J, Achtsamkeit. Konzeptuelle aspekte und ergebnisse zum Freiburger achtsamkeitsfragebogen. Verhaltenstherapie. 2006;16(1):33–40.
doi: 10.1159/000091521
de Bruin EI, Topper M, Muskens JG, Bögels SM, Kamphuis JH. Psychometric properties of the five facets mindfulness questionnaire (FFMQ) in a meditating and a non-meditating sample. Assessment. 2012;19(2):187–97.
pubmed: 22589426
doi: 10.1177/1073191112446654
DiClemente CC, Carbonari JP, Montgomery R, Hughes SO. The alcohol abstinence self-efficacy scale. J Stud Alcohol. 1994;55(2):141–8.
pubmed: 8189734
doi: 10.15288/jsa.1994.55.141
Gloster AT, Block VJ, Klotsche J, Villanueva J, Rinner MT, Benoy C, et al. Psy-Flex: a contextually sensitive measure of psychological flexibility. J Context Behav Sci. 2021;22:13–23.
doi: 10.1016/j.jcbs.2021.09.001
Dozois DJ, Westra HA, Collins KA, Fung TS, Garry JK. Stages of change in anxiety: psychometric properties of the University of Rhode Island Change Assessment (URICA) scale. Behav Res Ther. 2004;42(6):711–29.
pubmed: 15081886
doi: 10.1016/S0005-7967(03)00193-1
Bowen S, Chawla N, Marlatt G. Achtsamkeitsbasierte Rückfallprävention Bei Substanzabhängigkeit: Das MBRP-Programm. Weinheim: Beltz; 2012.
Roos CR, Kirouac M, Stein E, Wilson AD, Bowen S, Witkiewitz K. An open trial of rolling admission mindfulness-based relapse prevention (Rolling MBRP): feasibility, acceptability, dose-response relations, and mechanisms. Mindfulness. 2019;10:1062–73.
pubmed: 31354877
doi: 10.1007/s12671-018-1054-5
Wendiggensen P, Ghin F, Koyun AH, Stock A-K, Beste C. Pretrial theta band activity affects context-dependent modulation of response inhibition. J Cogn Neurosci. 2022;34(4):605–17.
pubmed: 35061021
doi: 10.1162/jocn_a_01816
Ekhtiari H, Zare-Bidoky M, Sangchooli A, Janes AC, Kaufman MJ, Oliver JA, et al. A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus. Nat Protoc. 2022;17(3):567–95.
pubmed: 35121856
pmcid: 9063851
doi: 10.1038/s41596-021-00649-4
Critchley HD, Wiens S, Rotshtein P, Öhman A, Dolan RJ. Neural systems supporting interoceptive awareness. Nat Neurosci. 2004;7(2):189–95.
pubmed: 14730305
doi: 10.1038/nn1176
Gramfort A, Luessi M, Larson E, Engemann DA, Strohmeier D, Brodbeck C, et al. MEG and EEG data analysis with MNE-Python. Front NeuroSci. 2013;7:70133.
doi: 10.3389/fnins.2013.00267
Bigdely-Shamlo N, Mullen T, Kothe C, Su K-M, Robbins KA. The PREP pipeline: standardized preprocessing for large-scale EEG analysis. Front Neuroinformatics. 2015;9:16.
doi: 10.3389/fninf.2015.00016
Cohen MX. Fluctuations in oscillation frequency control spike timing and coordinate neural networks. J Neurosci. 2014;34(27):8988–98.
pubmed: 24990919
pmcid: 6608248
doi: 10.1523/JNEUROSCI.0261-14.2014
Maris E, Oostenveld R. Nonparametric statistical testing of EEG-and MEG-data. J Neurosci Methods. 2007;164(1):177–90.
pubmed: 17517438
doi: 10.1016/j.jneumeth.2007.03.024
Jongkees BJ, Immink MA, Finisguerra A, Colzato LS. Transcutaneous vagus nerve stimulation (tVNS) enhances response selection during sequential action. Front Psychol. 2018;9:347635.
doi: 10.3389/fpsyg.2018.01159
Chaieb L, Antal A, Pisoni A, Saiote C, Opitz A, Ambrus GG, et al. Safety of 5 kHz tACS. Brain Stimul. 2014;7(1):92–6.
pubmed: 24064065
doi: 10.1016/j.brs.2013.08.004
Wang Y-M, Xu Y-Y, Zhai Y, Wu Q-Q, Huang W, Liang Y et al. Effect of transcutaneous auricular vagus nerve stimulation on protracted alcohol withdrawal symptoms in male alcohol-dependent patients. Front Psychiatry. 2021;12.
Reinhart RMG, Nguyen JA. Working memory revived in older adults by synchronizing rhythmic brain circuits. Nat Neurosci. 2019;22(5):820–7.
pubmed: 30962628
pmcid: 6486414
doi: 10.1038/s41593-019-0371-x
Cnaan A, Laird NM, Slasor P. Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data. Stat Med. 1997;16(20):2349–80.
pubmed: 9351170
doi: 10.1002/(SICI)1097-0258(19971030)16:20<2349::AID-SIM667>3.0.CO;2-E
Grant S, Colaiaco B, Motala A, Shanman R, Booth M, Sorbero M, et al. Mindfulness-based relapse prevention for substance use disorders: a systematic review and meta-analysis. J Addict Med. 2017;11(5):386–96.
pubmed: 28727663
pmcid: 5636047
doi: 10.1097/ADM.0000000000000338
Li W, Howard MO, Garland EL, McGovern P, Lazar M. Mindfulness treatment for substance misuse: a systematic review and meta-analysis. J Subst Abuse Treat. 2017;75:62–96.
pubmed: 28153483
doi: 10.1016/j.jsat.2017.01.008
Carroll KM. The profound heterogeneity of substance use disorders: implications for treatment development. Curr Dir Psychol Sci. 2021;30(4):358–64.
pubmed: 34483503
pmcid: 8415637
doi: 10.1177/09637214211026984