Positive Selection Drives the Evolution of the Structural Maintenance of Chromosomes (SMC) Complexes.
host-pathogen arms race
intragenomic conflict
meiotic cohesins
positive selection
structural maintenance of chromosomes
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
03 Sep 2024
03 Sep 2024
Historique:
received:
31
07
2024
revised:
20
08
2024
accepted:
30
08
2024
medline:
29
9
2024
pubmed:
28
9
2024
entrez:
28
9
2024
Statut:
epublish
Résumé
Structural Maintenance of Chromosomes (SMC) complexes are an evolutionary conserved protein family. In most eukaryotes, three SMC complexes have been characterized, as follows: cohesin, condensin, and SMC5/6 complexes. These complexes are involved in a plethora of functions, and defects in SMC genes can lead to an increased risk of chromosomal abnormalities, infertility, and cancer. To investigate the evolution of SMC complex genes in mammals, we analyzed their selective patterns in an extended phylogeny. Signals of positive selection were identified for condensin NCAPG, for two SMC5/6 complex genes (
Identifiants
pubmed: 39336750
pii: genes15091159
doi: 10.3390/genes15091159
pii:
doi:
Substances chimiques
Chromosomal Proteins, Non-Histone
0
Cell Cycle Proteins
0
Multiprotein Complexes
0
condensin complexes
0
Adenosine Triphosphatases
EC 3.6.1.-
Cohesins
0
DNA-Binding Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero della Salute
ID : Ricerca Corrente