Mechanistic Insights into Substrate Recognition of Human Nucleoside Diphosphate Kinase C Based on Nucleotide-Induced Structural Changes.

Humans Crystallography, X-Ray Substrate Specificity NM23 Nucleoside Diphosphate Kinases / metabolism Binding Sites Models, Molecular Protein Binding Protein Conformation Guanosine Diphosphate / metabolism Nucleoside-Diphosphate Kinase / chemistry Nucleotides / metabolism Cyclic AMP / metabolism Uridine Diphosphate / metabolism Magnesium / metabolism Adenosine Diphosphate / metabolism
X-ray structure enzymatic mechanism magnesium binding nme3 nucleoside diphosphate kinase C

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
10 Sep 2024
Historique:
received: 08 08 2024
revised: 05 09 2024
accepted: 08 09 2024
medline: 29 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Nucleoside diphosphate kinases (NDPKs) are encoded by

Identifiants

DOI: 10.3390/ijms25189768 PMID: 39337255
pubmed: 39337255
pii: ijms25189768
doi: 10.3390/ijms25189768
pii:
doi:

Substances chimiques

NM23 Nucleoside Diphosphate Kinases 0
Guanosine Diphosphate 146-91-8
Nucleoside-Diphosphate Kinase EC 2.7.4.6
Nucleotides 0
Cyclic AMP E0399OZS9N
Uridine Diphosphate 58-98-0
Magnesium I38ZP9992A
Adenosine Diphosphate 61D2G4IYVH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : DZHK (German Centre for Cardiovascular Research)
ID : MA-Wi2

Auteurs

Rezan Amjadi (R)

Institute of Molecular Biochemistry, Medical University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
ORCID: 0000-0001-6403-6182

Sebastiaan Werten (S)

Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
ORCID: 0000-0003-2244-9688

Santosh Kumar Lomada (SK)

Experimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167 Mannheim, Germany.

Clara Baldin (C)

Department of Microbiology, University of Innsbruck, Technikerstraße 25, 6020 Innsbruck, Austria.
ORCID: 0000-0002-3895-9511

Klaus Scheffzek (K)

Institute of Molecular Biochemistry, Medical University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.

Theresia Dunzendorfer-Matt (T)

Institute of Molecular Biochemistry, Medical University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
ORCID: 0000-0002-1315-6317

Thomas Wieland (T)

Experimental Pharmacology Mannheim, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Str. 13-17, 68167 Mannheim, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 68167 Mannheim, Germany.
ORCID: 0000-0001-8262-8261

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanistic Insights into Substrate...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Mechanistic Insights into Substrate...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Mechanistic Insights into Substrate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Phosphate Group Acceptor) › Nucleoside diphosphate kinase › NM23 Nucleoside Diphosphate kinases › Mechanistic Insights into Substrate...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Mechanistic Insights into Substrate...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Mechanistic Insights into Substrate...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Mechanistic Insights into Substrate...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Mechanistic Insights into Substrate...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides guanyliques › Guanosine diphosphate › Mechanistic Insights into Substrate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Phosphate Group Acceptor) › Nucleoside diphosphate kinase › Mechanistic Insights into Substrate...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Mechanistic Insights into Substrate...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP cyclique › Mechanistic Insights into Substrate...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides uridyliques › Uridine diphosphate › Mechanistic Insights into Substrate...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Magnésium › Mechanistic Insights into Substrate...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › ADP › Mechanistic Insights into Substrate...