Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic Wounds.

Animals Calgranulin B / metabolism Mice Extracellular Matrix / metabolism Humans Wound Healing Fibroblasts / metabolism Calgranulin A / metabolism Disease Models, Animal Male Mice, Inbred C57BL Toll-Like Receptor 4 / metabolism Chronic Disease Skin / metabolism
S100A8 S100A9 chronic wounds diabetes extracellular matrix fibroblasts iron overload

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
16 Sep 2024
Historique:
received: 21 08 2024
revised: 10 09 2024
accepted: 12 09 2024
medline: 29 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Chronic non-healing wounds are characterized by persistent inflammation, excessive matrix-degrading proteolytic activity and compromised extracellular matrix (ECM) synthesis. Previous studies showed that S100A8/A9 are strongly dysregulated in delayed wound healing and impair the proper function of immune cells. Here, we demonstrate an unrecognized pathological function of

Identifiants

DOI: 10.3390/ijms25189980 PMID: 39337466
pubmed: 39337466
pii: ijms25189980
doi: 10.3390/ijms25189980
pii:
doi:

Substances chimiques

Calgranulin B 0
Calgranulin A 0
Toll-Like Receptor 4 0
S100A9 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Hautnetz
ID : 2023
Organisme : Deutsche Forschungsgemeinschaft
ID : SA863/7-1
Organisme : Deutsche Forschungsgemeinschaft
ID : FR2671/5-1

Auteurs

Sandra Franz (S)

Department of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.
ORCID: 0000-0002-3449-2723

Marta Torregrossa (M)

Department of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.
ORCID: 0000-0001-8412-3646

Ulf Anderegg (U)

Department of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.
ORCID: 0000-0002-3993-9192

Anastasia Ertel (A)

Department of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

Anja Saalbach (A)

Department of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.
ORCID: 0000-0002-1084-3875

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Complexe antigénique L1 leucocytaire › Calgranuline B › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Matrice extracellulaire › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Complexe antigénique L1 leucocytaire › Calgranuline A › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-4 › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Dysregulated S100A9 Expression Impairs Matrix...
questionsmedicales.fr › Système tégumentaire › Peau › Dysregulated S100A9 Expression Impairs Matrix...