Cross-Effects in Folding and Phase Transitions of hnRNP A1 and C9Orf72 RNA G4 In Vitro.

Heterogeneous Nuclear Ribonucleoprotein A1 / metabolism G-Quadruplexes Humans C9orf72 Protein / genetics Phase Transition RNA / metabolism Heterogeneous-Nuclear Ribonucleoprotein Group A-B / metabolism Protein Binding Protein Folding Serine-Arginine Splicing Factors / metabolism
C9Orf72 G4 RNAs RNA binding protein SRSF biomolecular condensate hnRNP A1 liquid-liquid phase separation neurodegenerative diseases post-translational modifications

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
14 Sep 2024
Historique:
received: 14 08 2024
revised: 11 09 2024
accepted: 12 09 2024
medline: 29 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Abnormal intracellular phase transitions in mutant hnRNP A1 may underlie the development of several neurodegenerative diseases. The risk of these diseases increases upon

Identifiants

DOI: 10.3390/molecules29184369 PMID: 39339364
pubmed: 39339364
pii: molecules29184369
doi: 10.3390/molecules29184369
pii:
doi:

Substances chimiques

Heterogeneous Nuclear Ribonucleoprotein A1 0
C9orf72 Protein 0
RNA 63231-63-0
hnRNPA1 protein, human 0
Heterogeneous-Nuclear Ribonucleoprotein Group A-B 0
C9orf72 protein, human 0
Serine-Arginine Splicing Factors 170974-22-8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Russian Science Foundation
ID : 22-15-00129
Organisme : The State Assignment
ID : 17.002.24.800
Organisme : The Ministry of Science and Higher Education of the Russian Federation
ID : 075-15-2019-1669

Auteurs

Tatiana Vedekhina (T)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.
Lomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Vernadsky Avenue, 86, 119454 Moscow, Russia.
ORCID: 0000-0001-7356-397X

Julia Svetlova (J)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.

Iuliia Pavlova (I)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.
ORCID: 0000-0002-0984-7473

Nikolay Barinov (N)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.

Sabina Alieva (S)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.

Elizaveta Malakhova (E)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.

Pavel Rubtsov (P)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.
A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenov University), Trubetskaya Str., 8-2, 119991 Moscow, Russia.
ORCID: 0009-0008-3613-1789

Alina Shtork (A)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.

Dmitry Klinov (D)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.

Anna Varizhuk (A)

Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Malaya Pirogovskaya, 1a, 119435 Moscow, Russia.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Ribonucléoprotéines nucléaires hétérogènes › Ribonucléoprotéine nucléaire hétérogène du groupe A-B › Ribonucléoprotéine nucléaire hétérogène A1 › Cross-Effects in Folding and Phase Transitions...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › G-quadruplexes › Cross-Effects in Folding and Phase Transitions...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cross-Effects in Folding and Phase Transitions...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Protéine C9orf72 › Cross-Effects in Folding and Phase Transitions...
questionsmedicales.fr › Phénomènes chimiques › Transition de phase › Cross-Effects in Folding and Phase Transitions...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Cross-Effects in Folding and Phase Transitions...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Ribonucléoprotéines nucléaires hétérogènes › Ribonucléoprotéine nucléaire hétérogène du groupe A-B › Cross-Effects in Folding and Phase Transitions...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Cross-Effects in Folding and Phase Transitions...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Pliage des protéines › Cross-Effects in Folding and Phase Transitions...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Facteurs d'épissage des ARN › Facteurs d'épissage riches en sérine-arginine › Cross-Effects in Folding and Phase Transitions...