A specific folate activates serotonergic neurons to control C. elegans behavior.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
30 Sep 2024
30 Sep 2024
Historique:
received:
28
11
2023
accepted:
19
09
2024
medline:
1
10
2024
pubmed:
1
10
2024
entrez:
30
9
2024
Statut:
epublish
Résumé
Folates are B-group vitamins that function in one-carbon metabolism. Here we show that a specific folate can activate serotonergic neurons in C. elegans to modulate behavior through a pathway that requires the folate receptor FOLR-1 and the GON-2 calcium channel. FOLR-1 and GON-2 physically interact in a heterologous system, and both are expressed in the HSN and NSM serotonergic neurons. Both the folate 10-formyl-THF and a non-metabolic pteroate induce increases in the number of Ca
Identifiants
pubmed: 39349491
doi: 10.1038/s41467-024-52738-z
pii: 10.1038/s41467-024-52738-z
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Folic Acid
935E97BOY8
Folate Receptor 1
0
Calcium
SY7Q814VUP
Calcium Channels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8471Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R01GM134359
Informations de copyright
© 2024. The Author(s).
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